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An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells
TLDR
Injection of the mutant virus into p53-deficient human cervical carcinomas grown in nude mice caused a significant reduction in tumor size and caused complete regression of 60 percent of the tumors, raising the possibility that mutant adenoviruses can be used to treat certain human tumors. Expand
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
TLDR
It is demonstrated that the Aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies, which implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. Expand
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
TLDR
A cell-based screening strategy is described that has allowed us to identify compounds with ATR inhibitory activity in the nanomolar range that are being tested for cancer chemotherapy and are also very potent against ATM, ATR and the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). Expand
Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines*
TLDR
It is demonstrated that PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins and identified serine (Ser-474) as the likely autophosphorylation site in the kinase domain of PAK 4 in vivo, and suggested thatPAK4 activity is required for Ras-driven, anchorage-independent growth. Expand
Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.
TLDR
Using the two-hybrid system, it is shown that RalGDS-RBD interacts with H-ra, K-ras, and Rap, and with active but not with inactive point mutants of these Ras-like GTPases, and is a putative effector molecule for R-ras. Expand
The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.
TLDR
Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis and the potential role of aurora2 in human cancer is discussed. Expand
The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion
TLDR
An important role for HGK is suggested in cell transformation and invasiveness by an inhibition of H-RasV12-induced focus formation and expression of inactive, dominant-negative mutants of HGK in both fibroblast and epithelial cell lines. Expand
Intermediate filament reorganization during mitosis is mediated by p34 cdc2 phosphorylation of vimentin
TLDR
Vimentin is a substrate of p34cdc2 and phosphorylation of vimentin contributes to M phase reorganization of the IF network, which causes their disassembly by the purified kinase. Expand
Pten positively regulates brown adipose function, energy expenditure, and longevity.
TLDR
A role of Pten is uncovered in promoting energy expenditure, thus decreasing nutrient storage and its associated damage, and a synthetic PI3K inhibitor also increases energy expenditure and hyperactivates the BAT in mice. Expand
p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV- 40 T antigen proteins
TLDR
It is speculated that in vivo T124 phosphorylation may regulate the small but functionally significant amount of cytoplasmic SV-40 T antigen, and that many transcription regulatory proteins contain domains comprising potential CK-II-sites, cdc2- Sites, and NLS, which raises the possibility that the three elements represent a functional unit regulating nuclear protein import. Expand
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