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p16INK4a Ag:PrThr:Pt:Tiss:Ord:Immune stain

Known as: p16INK4a Antigen:Presence or Threshold:Point in time:Tissue, unspecified:Ordinal:Immune stain, p16INK4a , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica, p16INK4a Ag Tec Ql ImStn 
National Institutes of Health

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6 relations
AntigensBody tissueImmune stainPathology procedure

Papers overview

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Highly Cited
2014
Highly Cited
2014
Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.
Exposure to total body irradiation (TBI) induces not only acute hematopoietic radiation syndrome but also long-term or residual… 
Highly Cited
2011
Highly Cited
2011
p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms
Although caloric restriction (CR) has been shown to increase lifespan in various animal models, the mechanisms underlying this… 
Highly Cited
2006
Highly Cited
2006
Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53.
We have previously found that nonenzymatically glycated collagen I (GC), mimicking diabetic microenvironment, can induce… 
Highly Cited
2004
Highly Cited
2004
DNA‐methylation analysis identifies the E‐cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies
Silencing of tumor suppressor genes (TSG) by aberrant methylation (referred to as methylation) contributes to the pathogenesis of… 
Highly Cited
2004
Highly Cited
2004
Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines.
Flow cytometric analysis of fibroblasts, normal breast epithelial cells and breast or other cancer cell lines identified… 
Highly Cited
2003
Highly Cited
2003
Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture.
Highly Cited
2003
Highly Cited
2003
Expression of p16 INK4A in Papanicolaou smears containing atypical squamous cells of undetermined significance from the uterine cervix.
Highly Cited
2001
Highly Cited
2001
Detection of hypermethylation of thep16INK4A gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus
BACKGROUND/AIM Inactivation of the p16 INK4A(p16) tumour suppressor gene by promoter region hypermethylation has been… 
Highly Cited
1999
Highly Cited
1999
Acquisition of p16(INK4A) and p15(INK4B) gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia.
Although numerous somatic mutations that contribute to the pathogenesis of childhood acute lymphoblastic leukemia (ALL) have been… 
Highly Cited
1998
Highly Cited
1998
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
The p16(INK4a) (p16) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including… 
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