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Identification and characterization of ovarian cancer-initiating cells from primary human tumors.
It is asserted that epithelial ovarian cancers derive from a subpopulation of CD44(+)CD117(+) cells, thus representing a possible therapeutic target for this devastating disease.
An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)
It is shown how a 33-gene EMT Signature can sub-classify an OC cohort into four EMT States correlating with progression-free survival (PFS) and concluded that the characterisation of intermediate EMT states provides a new approach to better define EMT.
Primary treatment and prognostic factors of small cell neuroendocrine carcinoma of the uterine cervix: a Taiwanese Gynecologic Oncology Group study.
c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin–ATP-binding cassette G2 signaling
It is shown that c-Kit is not just a marker of OTICs, but also a critical mediator of the phenotype that can be a viable target for the treatment of ovarian cancer and shed light on its mechanisms of action.
SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway.
Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia.
ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome.
A long-term follow-up study of 176 cases with adult-type ovarian granulosa cell tumors.
An epigenetic marker panel for screening and prognostic prediction of ovarian cancer
- H. Su, H. Lai, Ya-Wen Lin, Y. Chou, Chin‐yu Liu, Mu‐Hsien Yu
- BiologyInternational journal of cancer
- 15 January 2009
Promoter hypermethylation of specific genes in critical pathways is common in ovarian cancer and has potential as a prognostic factor and a promising serum marker for early screening.
Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis
The present study demonstrated an association between Fas polymorphism and cervical carcinogenesis and deduced a possible effect of apoptosis of immune cells in this virus‐induced cancer.