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ortataxel

Known as: SB-T-101131 
A semisynthetic, second-generation taxane derivative with potential antineoplastic activity. Ortataxel binds to and stabilizes tubulin molecules… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

IDN 5109
Microtubule ProcessNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
A novel taxane, difluorovinyl-ortataxel, effectively overcomes paclitaxel-resistance in breast cancer cells.
2019
2019
Multicenter, single arm, phase II trial on the efficacy of ortataxel in recurrent glioblastoma
Background and purposeGlioblastoma (GBM) is the most aggressive and frequent subtype of all malignant gliomas. At the time of… 
2014
2014
The synthesis of novel taxoids for oral administration.
2012
2012
Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.
The effects on tubulin dynamics of paclitaxel, ortataxel and two recently developed taxol derivatives bearing a five-membered… 
2008
2008
Phase II study of ortataxel in taxane-resistant breast cancer
1066 Background: Ortataxel, a new-generation taxane, is not a substrate for the Pgp efflux pump. It is active in tumor models… 
Review
2005
Review
2005
Recent advances in the new generation taxane anticancer agents.
Recent advances in the design and preclinical evaluations of promising new generation taxane anticancer agents are reviewed in… 
Review
2004
Review
2004
An uncontrolled phase II study evaluating anti-tumor efficacy and safety of ortataxel (BAY 59-8862) in patients with taxane-resistant non-small cell lung cancer.
7136 Background: Ortataxel is a novel second-generation taxane, with potent growth inhibitory activity against human cell lines… 
2004
2004
An uncontrolled phase II study evaluating anti-tumor efficacy and safety of ortataxel (BAY 59–8862) in patients with taxane-resistant non-small cell lung cancer
7136 Background: Ortataxel is a novel second-generation taxane, with potent growth inhibitory activity against human cell lines… 
Highly Cited
2003
Highly Cited
2003
Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Overexpression of ATP-binding cassette transport proteins, including P-glycoprotein (Pgp), multidrug resistance (MDR) protein… 
2003
2003
Diastereoselective 14beta-hydroxylation of baccatin III derivatives.
14beta-Hydroxybaccatin III, a compound with limited availability by natural sources, is the starting material for the synthesis… 
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