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TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
The particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature ofTCM theory and developing new herb-oriented drugs. Expand
Regulated ATP release from astrocytes through lysosome exocytosis
It is found that lysosomes contain abundant ATP, which could be released in a stimulus-dependent manner and implicating physiological and pathological functions of regulated lysOSome exocytosis in these cells. Expand
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.
BACKGROUND Patients with melanoma that progresses on ipilimumab and, if BRAF(V600) mutant-positive, a BRAF or MEK inhibitor or both, have few treatment options. We assessed the efficacy and safety ofExpand
A Voltage-Gated Calcium-Selective Channel Encoded by a Sodium Channel-like Gene
BSC1 appears to be the prototype of a novel family of invertebrate voltage-dependent cation channels with a close structural and evolutionary relationship to voltage-gated Na(+) and Ca(2+) channels. Expand
The Microtubule Plus-End Tracking Protein EB1 Is Required for Kv1 Voltage-Gated K+ Channel Axonal Targeting
This work demonstrates that Kvbeta2 is responsible for targeting Kv1 channels to the axon and shows that KVbeta2 axonal targeting depends on its ability to associate with the microtubule plus-end tracking protein (+TIP) EB1. Expand
Early Response to Antipsychotic Drug Therapy as a Clinical Marker of Subsequent Response in the Treatment of Schizophrenia
This is the first study to prospectively show that early response/non-response to an antipsychotic (risperidone) is a reliable clinical marker of subsequent clinical outcomes and that a ‘switching’ strategy based on this information may lead to greater clinical improvement than staying on a drug for a longer period in some patients. Expand
Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice.
A novel systems pharmacology model that integrates oral bioavailability screening, drug-likeness evaluation, blood-brain barrier permeation, target identification and network analysis has been established to investigate the herbal medicines. Expand
FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer.
Findings suggest that FOXO1A is the 13q14 tumor suppressor gene, at least in prostate cancer, as a well-established negative effector in the phosphatidylinositol 3-kinase/AKT signaling pathway would impair the therapeutic effect of phosphate-based inhibitors in cancer treatment. Expand
Different roles of rhizosphere effect and long-term fertilization in the activity and community structure of ammonia oxidizers in a calcareous fluvo-aquic soil
The results indicate that AOB rather than AOA functionally dominate ammonia oxidation in the calcareous fluvo-aquic soil, and that rhizosphere effect and fertilization regime play different roles in the activity and community structures of AOB and AOA. Expand
Sox7 Is an Independent Checkpoint for β-Catenin Function in Prostate and Colon Epithelial Cells
It is discovered that Sox7 protein physically interacts with β-catenin and suppresses β- catenin–mediated transcription by depleting active β-Catenin, and suggests that Sox 7 is a tumor suppressor that functions as an independent checkpoint for β-catsenin transcriptional activity. Expand