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nutlin-3A
A small molecule and MDM2 (murine double minute 2) inhibitor, with potential antineoplastic activity. In cancer cells, nutlin-3a antagonizes the…
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National Institutes of Health
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Related topics
Related topics
4 relations
MDM2 protein, human
NCIt Antineoplastic Agent Terminology
Positive Regulation of Apoptosis
Broader (1)
nutlin 3
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MDM 2p 53-FOXM 1 axis in well-differentiated intestinal neuroendocrine tumors
F. Briest
,
I. Grass
,
+20 authors
P. Grabowski
2017
Corpus ID: 207785777
Received: 3/23/2017 9:32:31 AM Accepted: 9/13/2017 Published(online): 9/14/2017 --------------Mechanisms of targeting the MDM2…
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2017
2017
Nutlin-3a-PLGA微球促大鼠脊髓损伤后的运动功能恢复
Xiao Tan
,
Xiao-Xiao Qin
,
+11 authors
Le-Huan Yu
2017
Corpus ID: 209223339
目的探讨Nutlin-3a-PLGA微球对大鼠脊髓损伤后运动功能恢复的影响。 方法采用单乳化法制备Nutlin-3a-PLGA微球。健康成年SD大鼠采用随机数字表法分为单纯损伤组、生理盐水微球治疗组和Nutlin-3a-PLGA微球治疗组，每组12只；另取3…
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2016
2016
A Knock-in Reporter for a Novel AR-Targeted Therapy
Chunhong Yan
2016
Corpus ID: 51745570
Abstract : Since castration resistance of prostate cancer is often caused by AR overexpression, down-regulation of AR expression…
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2013
2013
Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary Hypertension
NathalieMouraret
,
ElisabethMarcos
,
+9 authors
SergeAdnot
2013
Corpus ID: 81521830
Background—Induction of cellular senescence through activation of the p53 tumor suppressor protein is a new option for treating…
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2013
2013
MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice
X. Li
,
K. Cheng
,
C. Chen
,
B. Wang
,
K. Lam
,
A. Xu
2013
Corpus ID: 86091201
introduction: Cigarette smoking (CS) is the major cause of chronic obstructive pulmonary disease (COPD) which is the fourth…
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2012
2012
Cell Receptor NKG 2 D KillerExpression of ULBP 2 , a Stress-Induced Ligand of the Natural Tumor Suppressive MicroRNAs miR-34 a / c Control Cancer Cell
A. Heinemann
,
Fang Zhao
,
+5 authors
A. Paschen
2012
Corpus ID: 49216793
Malignant cells express ligands for the natural killer cell immunoreceptor NKG2D, which sensitizes to early recognition and…
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2011
2011
Mdm 2 Promotes Systemic Lupus Erythematosus and Lupus Nephritis
Ramanjaneyulu Allam
,
Sufyan G. Sayyed
,
O. Kulkarni
,
J. Lichtnekert
,
H. Anders
2011
Corpus ID: 44197792
Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed against multiple nuclear autoantigens. Although…
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2008
2008
SNP309 as predictor for sensitivity of CLL cells to the MDM2 inhibitor nutlin-3a.
Irina Seyfried
,
S. Hofbauer
,
M. Stoecher
,
R. Greil
,
I. Tinhofer
Blood
2008
Corpus ID: 206871333
To the editor: From a recent comprehensive genomic analysis focusing on loss of heterozygosity, p53 deletion/mutation, and other…
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2008
2008
The single nucleotide polymorphism MDM2-SNP309 influences sensitivity of B-CLL cells to the non-genotoxic activator of the p53 pathway Nutlin-3a
I. Tinhofer
,
Irina Seyfried
,
M. Stoecher
,
S. Hofbauer
,
P. Daniel
,
R. Greil
2008
Corpus ID: 74041778
14552 Background: The single nucleotide polymorphism (SNP) at position 309 in the promoter region of MDM2, a negative regulator…
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2007
2007
Cyclin-Dependent Kinase Inhibitors Sensitize Tumor Cells to Nutlin-Induced Apoptosis : a Potent Drug Combination Chit
Fang Cheok
,
A. Dey
,
D. Lane
2007
Corpus ID: 31073509
Current chemotherapy focuses on the use of genotoxic drugs that may induce general DNA damage in cancer cells but also high…
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