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nutlin-3A

A small molecule and MDM2 (murine double minute 2) inhibitor, with potential antineoplastic activity. In cancer cells, nutlin-3a antagonizes the… 
National Institutes of Health

Related topics

Related topics

4 relations
MDM2 protein, humanNCIt Antineoplastic Agent TerminologyPositive Regulation of Apoptosis

Broader (1)

nutlin 3

Papers overview

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Highly Cited
2014
Highly Cited
2014
p53-directed translational control can shape and expand the universe of p53 target genes
The increasing number of genome-wide transcriptome analyses focusing on p53-induced cellular responses in many cellular contexts… 
Highly Cited
2013
Highly Cited
2013
Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach.
2013
2013
Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides
Pharmacological modulation of p53 activity is an attractive therapeutic strategy in cancers with wild-type p53. Presently in… 
2013
2013
In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition
HDM2 binds to the p53 tumour suppressor and targets it for proteosomal degradation. Presently in clinical trials, the small… 
2012
2012
Decreased sensitivity of 17p‐deleted chronic lymphocytic leukemia cells to a small molecule BCL‐2 antagonist ABT‐737
Despite the high complete response rates achieved with fludarabine‐based regimens, relapse is inevitable in chronic lymphocytic… 
2012
2012
Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships.
Highly Cited
2009
Highly Cited
2009
Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions
MDM2 belongs to a class of ring-finger domain–containing ubiquitin ligases that mediate the proteasomal degradation of numerous… 
2008
2008
NPM1-mutated acute myeloid leukaemia occurring in JAK2-V617F+ primary myelofibrosis: de-novo origin?
NPM1 -mutated acute myeloid leukaemia occurring in JAK2-V617F + primary myelofibrosis: de-novo origin? 
2008
2008
SNP309 as predictor for sensitivity of CLL cells to the MDM2 inhibitor nutlin-3a.
To the editor: From a recent comprehensive genomic analysis focusing on loss of heterozygosity, p53 deletion/mutation, and other… 
2006
2006
Mdm 2 inhibitor Nutlin-3 a induces p 53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to Fludarabine in chronic…
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