nutlin-3A

A small molecule and MDM2 (murine double minute 2) inhibitor, with potential antineoplastic activity. In cancer cells, nutlin-3a antagonizes the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2018
05101520062018

Papers overview

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2011
2011
PURPOSE Although mutations in the TP53 gene occur in half of all cancers, approximately 90% of Ewing sarcomas retain a functional… (More)
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2011
2011
Retinoblastoma is a rare childhood cancer of the retina that begins in utero and is diagnosed in the first years of life. The… (More)
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2011
2011
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Despite concerted efforts to… (More)
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2011
2011
Nutlin-3a is an MDM2 inhibitor that is under investigation in preclinical models for a variety of pediatric malignancies… (More)
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Highly Cited
2008
Highly Cited
2008
Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is… (More)
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2008
2008
Numerous studies in chronic lymphocytic leukaemia (CLL) have demonstrated the adverse prognostic significance of structural… (More)
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2008
2008
p53 Activity is controlled in large part by MDM2, an E3 ubiquitin ligase that binds p53 and promotes its degradation. The MDM2… (More)
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Highly Cited
2007
Highly Cited
2007
MDM2 is a critical negative regulator of the p53 tumor suppressor protein. Recently, small-molecule antagonists of MDM2, the… (More)
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2007
2007
Cellular senescence is emerging as an important in vivo anticancer response elicited by multiple stresses, including currently… (More)
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Highly Cited
2006