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nutlin 3

Known as: nutlin-3 
 
National Institutes of Health

Papers overview

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2012
2012
MYCN amplification is a major biomarker of poor prognosis, occurring in 25–30% of neuroblastomas. MYCN has contradictory roles in… Expand
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Highly Cited
2011
Highly Cited
2011
Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma, rhabdomyosarcoma, and melanoma) were… Expand
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Highly Cited
2011
Highly Cited
2011
Wild-type p53 is a stress-responsive tumor suppressor and potent growth inhibitor. Genotoxic stresses (for example, ionizing and… Expand
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Review
2011
Review
2011
Nutlin-3 is a small molecule inhibitor of the MDM2/p53 interaction, which leads to the non-genotoxic p53 stabilization… Expand
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Highly Cited
2008
Highly Cited
2008
Nutlin-3, a small molecule inhibitor, activates p53 by disrupting p53-HDM2 association. In this study, we found that Nutlin-3… Expand
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Highly Cited
2008
Highly Cited
2008
Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is… Expand
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Highly Cited
2007
Highly Cited
2007
Nutlin-3, a nongenotoxic activator of the p53 pathway, dose-dependently (range 0.1 to 10 micromol/L) inhibited the formation of… Expand
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Highly Cited
2006
Highly Cited
2006
The p53 tumor suppressor retains its wild-type conformation and transcriptional activity in half of all human tumors, and its… Expand
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Highly Cited
2006
Highly Cited
2006
Deletions and/or mutations of p53 are relatively rare and late events in the natural history of B-cell chronic lymphocytic… Expand
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Highly Cited
2006
Highly Cited
2006
Hdm2 and HdmX coordinately regulate the stability and function of p53. Each is overexpressed in subsets of many different types… Expand
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