MDM2 protein, human

Known as: Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, human, double minute 2 protein, human, HDM2 
E3 ubiquitin-protein ligase Mdm2 (491 aa, ~55 kDa) is encoded by the human MDM2 gene. This protein is involved in the mediation of the ubiquitination… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and… (More)
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Highly Cited
2004
Highly Cited
2004
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonable to assume that naturally… (More)
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Review
2003
Review
2003
Activation of the p53 protein protects the organism against the propagation of cells that carry damaged DNA with potentially… (More)
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Highly Cited
2003
Highly Cited
2003
The gene encoding p53 mediates a major tumor suppression pathway that is frequently altered in human cancers. p53 function is… (More)
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Highly Cited
2001
Highly Cited
2001
HER-2/neu amplification or overexpression can make cancer cells resistant to apoptosis and promotes their growth. p53 is crucial… (More)
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Highly Cited
1998
Highly Cited
1998
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading… (More)
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Highly Cited
1998
Highly Cited
1998
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor suppression. p16INK4 binds to and inhibits the… (More)
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Highly Cited
1997
Highly Cited
1997
DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional mechanisms. Here we show that phosphorylation… (More)
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Highly Cited
1995
Highly Cited
1995
THE gene p53 encodes a transcriptional activator1,2 of genes involved in growth arrest3,4, DNA repair5 and apoptosis6–8. Loss of… (More)
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Highly Cited
1993
Highly Cited
1993
THE tumour-suppressor gene p53 is inactivated in most human malignancies1 either by missense mutations1 or by binding to… (More)
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