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MDM2 protein, human

Known as: Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, human, double minute 2 protein, human, HDM2 
E3 ubiquitin-protein ligase Mdm2 (491 aa, ~55 kDa) is encoded by the human MDM2 gene. This protein is involved in the mediation of the ubiquitination… 
National Institutes of Health

Related topics

Related topics

21 relations
ATM Signaling PathwayAndrogen Receptor Regulation PathwayCTCF PathwayCell Cycle

Broader (1)

mdm2 protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
MicroRNA-410 Suppresses Migration and Invasion by Targeting MDM2 in Gastric Cancer
Gastric cancer is one of the most frequent malignancies in tumors in the East Asian countries. Identifying precise prognostic… 
Review
2011
Review
2011
Small-molecule inhibitors of the p53-MDM2 interaction.
The p53 tumor suppressor is controlled by MDM2, which binds p53 and negatively regulates its transcriptional activity and… 
Highly Cited
2007
Highly Cited
2007
MDMX Promotes Proteasomal Turnover of p21 at G1 and Early S Phases Independently of, but in Cooperation with, MDM2
ABSTRACT We have shown previously that MDM2 promotes the degradation of the cyclin-dependent kinase inhibitor p21 through a… 
Highly Cited
2006
Highly Cited
2006
Excess HDM2 Impacts Cell Cycle and Apoptosis and Has a Selective Effect on p53-dependent Transcription*
Mutational inactivation of p53 is only one of the ways that tumors lose p53 function. An alternate route is through… 
Highly Cited
2006
Highly Cited
2006
The p53 Pathway and Outcome among Patients with T1G3 Bladder Tumors
Purpose: The aim was to analyze Tp53 and HDM2 in T1G3 bladder tumors and to determine the prognostic value of their alterations… 
Highly Cited
2002
Highly Cited
2002
Clinical significance of p53, mdm2, and bcl-2 proteins in renal cell carcinoma.
Review
2002
Review
2002
Function and dysfunction of the human oncoprotein MDM2.
The protein MDM2 coded by the human homologue of mouse double minute-2 (mdm2) gene frequently overexpresses in malignant human… 
Highly Cited
1998
Highly Cited
1998
A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells
The MDM2 oncogene product is a regulator of the p53 tumor suppressor. MDM2 is cleaved by Caspase 3 (CPP32) during apoptosis after… 
Highly Cited
1997
Highly Cited
1997
The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation
The oncogene product MDM2 can be phosphorylated by protein kinase CK2 in vitro 0.5 – 1 mol of phosphate were incorporated per mol… 
Highly Cited
1996
Highly Cited
1996
The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein.
MDM2 gene overexpression has been implicated in the pathogenesis of human neoplasia via inhibition of the p53 tumor-suppressor… 
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