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For many decades, the design of new nucleoside analogs as potential therapeutic agents focused on both sugar and nucleobase… Expand Targeting drugs to specific organs, tissues, or cells is an attractive strategy for enhancing drug efficacy and reducing side… Expand Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common… Expand Nucleoside diphosphate (NDP) kinase is a ubiquitous nonspecific enzyme that evidently is designed to catalyze in vivo ATP… Expand BACKGROUND
There are 17 crystal structures of nucleoside monophosphate kinases known. As expected for kinases, they show large… Expand From an analysis of current data on 16 protein structures with defined nucleotide-binding sites consensus motifs were determined… Expand 8-Oxoguanine nucleotide can pair with cytosine and adenine nucleotides at almost equal efficiencies. Once 8-oxodGTP is formed in… Expand The thymidine analog 3'-azido-3'-deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV… Expand The mechanism of translocation in vitro of sugar nucleotides and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) into the lumen… Expand The levels of acyclo-GMP (9([2-(phosphonooxy)ethoxy]methyl)guanine) phosphorylating activity were not significantly different… Expand