Enzymatic markers of neoplastic transformation and regulation of purine and pyrimidine metabolism.

@article{Weber1976EnzymaticMO,
  title={Enzymatic markers of neoplastic transformation and regulation of purine and pyrimidine metabolism.},
  author={George R. Weber and Robert C. Jackson and John C. Williams and Frederick J. Goulding and T J Eberts},
  journal={Advances in enzyme regulation},
  year={1976},
  volume={15},
  pages={
          53-77
        }
}
Abstract Enzymes that were identified as transformation-linked in the spectrum of hepatomas of different growth rates in the rat were used as markers of malignancy for liver tumors in rat and in man. The applicability of the enzymatic pattern was examined in kidney tumors of the rat, in lymphomas of the mouse and in hypernephroma-type kidney tumors in human. The impact of altered gene expression, as manifested in the enzymic imbalance, was further investigated by determining the concentration… CONTINUE READING