nuclease

Known as: nucleases 
 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
In the frame of modern agriculture facing the predicted increase of population and general environmental changes, the securement… (More)
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Highly Cited
2014
Highly Cited
2014
Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases (RGNs) are highly efficient genome… (More)
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Highly Cited
2013
Highly Cited
2013
The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to genomic loci by means of single-guide RNAs… (More)
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Highly Cited
2013
Highly Cited
2013
Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases (RGNs) have rapidly emerged as a facile… (More)
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Highly Cited
2013
Highly Cited
2013
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II… (More)
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Highly Cited
2010
Highly Cited
2010
Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a… (More)
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Highly Cited
2008
Highly Cited
2008
Formation of single-strand DNA (ssDNA) tails at a double-strand break (DSB) is a key step in homologous recombination and DNA… (More)
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Highly Cited
2007
Highly Cited
2007
Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification efficiencies (>10%) by introducing a… (More)
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Highly Cited
2005
Highly Cited
2005
Permanent modification of the human genome in vivo is impractical owing to the low frequency of homologous recombination in human… (More)
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Highly Cited
1999
Highly Cited
1999
Large-scale screening for known polymorphisms will require techniques with few steps and the ability to automate each of these… (More)
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