M. Paterson

Publications129
h-index39
Citations5,524
Highly Influential Citations107
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Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.
Cells cultured from most patients suffering from the sunlight-sensitive hereditary disorder xeroderma pigmentosum are defective in the ability to excise ultraviolet light (UV)-induced pyrimidine… Expand
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Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome.
We have prospectively analyzed Wilms' tumors from 232 patients registered on the National Wilms' Tumor Study for loss of heterozygosity (LOH) on chromosomes 11p, 16q, and 1p. These chromosomal… Expand
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Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer.
Drawing upon the comprehensive population-based Northern Alberta Breast Cancer Registry containing 704 patients with histologically negative axillary lymph nodes who have been followed for 5-16… Expand
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Localization of an ataxia-telangiectasia gene to chromosome 11q22–23
Ataxia-telangiectasia (AT) is a human autosomal recessive disorder of childhood1,2 characterized by: (1) progressive cerebellar ataxia with degeneration of Purkinje cells; (2) hypersensitivity of… Expand
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DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays.
The production and rejoining of DNA single-strand and double-strand breaks have been monitored in monolayer cultures of proliferating human skin fibroblasts by means of sensitive techniques. Cells… Expand
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Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.
FHIT (fragile histidine triad), a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human… Expand
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Ataxia telangiectasia: an inherited human disorder involving hypersensitivity to ionizing radiation and related DNA-damaging chemicals.
This review is primarily devoted to ataxia telangiectasia - a complex multisystem disorder exhibiting many characteristics, both in vivo and in vitro, expected of an ionizing radiation analogue of… Expand
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A third Wilms' tumor locus on chromosome 16q.
Loss of heterozygosity studies have been used to identify chromosomal regions which are frequently deleted and thus indicate areas which may harbor tumor suppressor genes. As a result, both the WT1… Expand
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Factors influencing efficiency and reproducibility of polybrene-assisted gene transfer
A systematic investigation of factors influencing the efficiency of polybrene-assisted gene transfer for both transient and stable foreign gene expression was carried out utilizing NIH 3T3… Expand
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Use of UV endonuclease from Micrococcus luteus to monitor the progress of DNA repair in UV-irradiated human cells.
Abstract A sensitive enzymatic assay has been developed to follow the progress of NDA repair in human cells exposed to UV radiation. The assay employs an endonuclease selectively active at sites… Expand
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