nogalose
National Institutes of Health
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Nogalamycin is a polyketide antibiotic produced by Streptomyces nogalater Lv65. Antibiotic is glycosylated with nogalose and…
Certain organisms, can during periods of limited resources, adapt their metabolism to enable biosynthesis of secondary…
The structure of the 1:1 nogalamycin:d(ATGCAT)2 complex has been determined in solution from high-resolution NMR data and…
Defects in DNA, e.g., unpaired/bulged nucleotides, are repaired by specific repair enzymes. Understanding the dynamics and…
The antibiotic nogalamycin, a drug with high specificity for TG and CG steps in double-stranded DNA, has been crystallized as a 1…
The interaction of the anthracycline antibiotic nogalamycin with the single 5'-CpG binding site at the centre of the hexamer…
The anthracycline antibiotic nogalamycin differs from the more common daunomycin-type anthracyclines by substitution on both ends…
The nogalamycin-d(A-G-C-A-T-G-C-T) complex (two drugs per duplex) has been generated in aqueous solution and its structure…
The interactions between a novel antitumor drug nogalamycin with the self-complementary DNA hexamer d(CGTACG) have been studied…
The three-dimensional molecular structures of the complexes between an interesting antitumor drug, nogalamycin, and two DNA…