niraparib

Known as: 2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 
An inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib inhibits PARP activity, enhancing the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2018
051020122018

Papers overview

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2018
2018
Niraparib is an oral poly(ADP ribose) polymerase (PARP) inhibitor that is currently approved by the United States Food and Drug… (More)
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2017
2017
To the Editor: Mirza and colleagues (Dec. 1 issue)1 report encouraging results regarding niraparib maintenance therapy in… (More)
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Review
2017
Review
2017
INTRODUCTION Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors are being developed in maintenance and recurrence… (More)
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Highly Cited
2016
Highly Cited
2016
BACKGROUND Niraparib is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) 1/2 inhibitor that has shown clinical… (More)
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2015
2015
Poly(ADP-ribose) polymerases (PARPs) are involved in DNA repair following damage by endogenous or exogenous processes. It has… (More)
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2015
2015
Cells with homologous recombination (HR) deficiency, most notably caused by mutations in the BRCA1 or BRCA2 genes, are sensitive… (More)
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Highly Cited
2014
Highly Cited
2014
Anti-PARP drugs were initially developed as catalytic inhibitors to block the repair of DNA single-strand breaks. We recently… (More)
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2014
2014
The aim of this study was to assess niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase (PARP) inhibitor, for its ability to… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Poly(ADP-ribose) polymerase (PARP) is implicated in DNA repair and transcription regulation. Niraparib (MK4827) is an… (More)
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Highly Cited
2012
Highly Cited
2012
Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA… (More)
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