Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Poly(ADP-ribose) Polymerase Inhibitors

Known as: Poly (ADP-Ribose) Polymerase Inhibitor, PARP Inhibitors, PARP inhibitor 
A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed… Expand
Highly Cited
2016
Highly Cited
2016
Therapeutic drugs that block DNA repair, including poly(ADP-ribose) polymerase (PARP) inhibitors, fail due to lack of tumor… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Review
2015
Review
2015
Recent findings indicate that a major mechanism by which poly(ADP-ribose) polymerase (PARP) inhibitors kill cancer cells is by… Expand
  • figure 1
  • figure 3
Highly Cited
2013
Highly Cited
2013
Anti-PARP drugs were initially developed as catalytic inhibitors to block the repair of DNA single-strand breaks. We recently… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Highly Cited
2012
Highly Cited
2012
Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2012
Highly Cited
2012
UNLABELLED There is a need to improve treatments for metastatic breast cancer. Here, we show the activation of the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Review
2010
Review
2010
Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Highly Cited
2008
Highly Cited
2008
Whereas target-specific drugs are available for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2007
Highly Cited
2007
Poly(ADP-ribose) polymerase (PARP)-1 (EC 2.4.2.30) is a nuclear enzyme that promotes the base excision repair of DNA breaks… Expand
  • figure 1
  • table 1
  • table 1
  • table 2
  • figure 3
Highly Cited
2005
Highly Cited
2005
We have previously demonstrated that deficiency of either the BRCA1 or BRCA2 breast cancer susceptibility proteins confers… Expand