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nintedanib

Known as: Intedanib, Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate 
An orally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Antineoplastic AgentsEnzyme InhibitorsIndoles

Narrower (3)

BIBF 1120Multitargeted Tyrosine Kinase Inhibitor BIBF 1120vargatef
Inhibition of Cell ProliferationNCIt Antineoplastic Agent TerminologyPositive Regulation of ApoptosisReceptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Efficacy of nintedanib and docetaxel in patients with advanced lung adenocarcinoma treated with first-line chemotherapy and second-line immunotherapy in the nintedanib NPU program
PurposeBoth nintedanib/docetaxel and anti‐PD‐1/PD‐L1 immunotherapies have demonstrated efficacy as second‐line treatment of… 
Review
2019
Review
2019
Application of nintedanib and other potential anti-fibrotic agents in fibrotic diseases.
Nintedanib, a Food and Drug Administration-approved drug for the treatment of patients with idiopathic pulmonary fibrosis (IPK… 
2019
2019
Risk of anastomotic dehiscence in patients with pulmonary fibrosis transplanted while receiving anti-fibrotics: Experience of the Australian Lung Transplant Collaborative.
Review
2017
Review
2017
Clinical use of nintedanib in patients with idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a rare lung disease characterised by progressive loss of lung function, dyspnoea and cough… 
2017
2017
Efficacy and Safety of Nintedanib Plus Docetaxel in Patients with Advanced Lung Adenocarcinoma: Complementary and Exploratory Analyses of the Phase III LUME-Lung 1 Study
BackgroundNintedanib is a triple angiokinase inhibitor approved with docetaxel for adenocarcinoma non-small cell lung cancer… 
Review
2015
Review
2015
Antiangiogenic agents in gynecological cancer: State of art and perspectives of clinical research.
2014
2014
Synthesis and biological evaluation of novel oxindole-based RTK inhibitors as anti-cancer agents.
2014
2014
Treatments for idiopathic pulmonary fibrosis.
2014
2014
Effect of baseline emphysema on reduction in FVC decline with nintedanib in the INPULSIS™ trials
Background: The INPULSIS™ trials were two replicaterandomized, placebo-controlled, 52-week Phase III trials that assessed the… 
Review
2008
Review
2008
Update in diffuse parenchymal lung disease 2007.
It is now widely accepted that the diagnostic reference standardfor interstitial lung disease is multidisciplinary evaluation… 
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