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nicotine metabolism

Known as: metabolism nicotine, nicotine metabolic process 
The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. [GOC:sm, ISBN:0198547684]
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The genetic basis of addictive disorders.
Highly Cited
2006
Highly Cited
2006
Female sex and oral contraceptive use accelerate nicotine metabolism
Review
2005
Review
2005
Metabolism and Disposition Kinetics of Nicotine
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for… 
Highly Cited
2004
Highly Cited
2004
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.
Genetically variable CYP2A6 is the primary enzyme that inactivates nicotine to cotinine. Our objective was to investigate allele… 
Highly Cited
2004
Highly Cited
2004
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity
Review
2004
Review
2004
Nicotine, its metabolism and an overview of its biological effects.
Highly Cited
2002
Highly Cited
2002
Accelerated metabolism of nicotine and cotinine in pregnant smokers.
Cigarette smoking is the foremost modifiable risk factor for adverse pregnancy outcomes. Nicotine is a suspected fetal… 
Highly Cited
1999
Highly Cited
1999
Ethnic differences in N-glucuronidation of nicotine and cotinine.
We previously reported that the metabolism of cotinine, the proximate metabolite of nicotine, is significantly slower in black… 
Highly Cited
1998
Highly Cited
1998
Nicotine metabolism and intake in black and white smokers.
CONTEXT Racial differences in tobacco-related diseases are not fully explained by cigarette-smoking behavior. Despite smoking… 
Highly Cited
1997
Highly Cited
1997
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of variation in the metabolism of nicotine… 
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