Metabolism and Disposition Kinetics of Nicotine

@article{Hukkanen2005MetabolismAD,
  title={Metabolism and Disposition Kinetics of Nicotine},
  author={Janne Hukkanen and Pleyton Jacob and Neal L. Benowitz},
  journal={Pharmacological Reviews},
  year={2005},
  volume={57},
  pages={115 - 79}
}
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for several diseases, and a useful probe drug for phenotyping cytochrome P450 2A6 (CYP2A6. [...] Key Method Absorption, distribution, metabolism, and excretion of nicotine and related compounds are reviewed. Enzymes involved in nicotine metabolism including cytochrome P450 enzymes, aldehyde oxidase, flavin-containing monooxygenase 3, amine N-methyltransferase, and UDP…Expand
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