Metabolism and Disposition Kinetics of Nicotine

@article{Hukkanen2005MetabolismAD,
  title={Metabolism and Disposition Kinetics of Nicotine},
  author={Janne Hukkanen and Pleyton Jacob and Neal L. Benowitz},
  journal={Pharmacological Reviews},
  year={2005},
  volume={57},
  pages={115 - 79}
}
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for several diseases, and a useful probe drug for phenotyping cytochrome P450 2A6 (CYP2A6. [] Key Method Absorption, distribution, metabolism, and excretion of nicotine and related compounds are reviewed. Enzymes involved in nicotine metabolism including cytochrome P450 enzymes, aldehyde oxidase, flavin-containing monooxygenase 3, amine N-methyltransferase, and UDP…
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CYP2A6 genetic variation and its impact on in vivo nicotine kinetics is reviewed, including a description of the individual variants, different phenotyping approaches for assessing in vivo CYP2A 6 activity and other sources of variation in nicotine metabolism such as gender.
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Type of the nicotine metabolism may be a potential predictor of the clinical outcomes in patients with cardiovascular disease, addicted to nicotine and in those using NRT.
Biochemistry of nicotine metabolism and its relevance to lung cancer
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  • 2021
CYP2A6 gene polymorphisms impact to nicotine metabolism
TLDR
The variation of nicotine metabolism activity could alter nicotine plasma levels, and in slow metabolizers, nicotine plasma level may increase and results in nicotine toxicity.
Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation.
TLDR
The metabolic pathways of the glucuronidation of nicotine, cotinine, and trans-3'-hydroxycotinine in humans would be one of the causal factors for the interindividual differences in nicotine metabolism.
An investigation of nicotine metabolism in mice : the impact of pharmacological inhibition and genetic influences on nicotine pharmacology.
TLDR
Nicotine metabolism in mice in vitro was mediated by CYP2A5, and this enzyme was responsible for over 70% and 90% of the metabolism of nicotine to cotinine andcotinine to 3-hydroxycotinine as shown by immuno-inhibition studies, respectively.
Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse.
TLDR
The isoenzymes (e.g., cytochrome P450, glucuronyltransferases, esterases and reductases) involved in the metabolism of drugs and some pharmacokinetic data are discussed and the relevance of such data is discussed for predicting possible interactions with other xenobiotics, understanding pharmacokinetics behavior and pharmacogenomic variations, assessing toxic risks, developing suitable toxicological analysis procedures, and finally for interpretating drug testing results.
Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo
TLDR
The metabolism of nicotine in mouse is very similar to that in man and, therefore, that the mouse is a suitable model for testing novel chemical inhibitors of human CYP2A6.
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TLDR
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