Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
The HTTLPR L(A)L( a) genotype exerts a moderate effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD.
The genetics of addictions: uncovering the genes
The addictions are common chronic psychiatric diseases that today are prevented and treated using relatively untargeted and only partially effective methods, but future understanding of addictions will be enhanced by the identification of genes that have a role in altered substance-specific vulnerabilities such as variation in drug metabolism or drug receptors.
Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.
An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk.
- Xianzhang Hu, G. Oroszi, J. Chun, Tom L. Smith, D. Goldman, M. Schuckit
- MedicineAlcoholism: Clinical and Experimental Research
Support is found for a relationship between the HTTLPR L and GABAAalpha6 Ser385 alleles to low alcohol LR and to alcoholism in a prospectively studied cohort evaluated for LR in young adulthood and before the onset of alcohol dependence.
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential…
Catechol-O-Methyltransferase val158met Genotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex
It is concluded that genetic variations can account for a substantial part of interindividual variance in task-related brain activation and that increased limbic and prefrontal activation elicited by unpleasant stimuli in subjects with more met158 alleles might contribute to the observed lower emotional resilience against negative mood states.
Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.
- A. Malhotra, L. Kestler, C. Mazzanti, J. Bates, T. Goldberg, D. Goldman
- Psychology, BiologyAmerican Journal of Psychiatry
- 1 April 2002
These data are consistent with those of previous studies, suggesting that a functional genetic polymorphism may influence prefrontal cognition.
The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption
Evidence linking the alcohol flushing response (predominantly due to ALDH2 deficiency) with a much higher risk of esophageal cancer from alcohol consumption is discussed.