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neurofibrillary tangle (cell component)

Known as: neurofibrillary tangle 
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell… 
National Institutes of Health

Related topics

Related topics

1 relation
Neurofibrillary degeneration (morphologic abnormality)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
The role of microglia activation by pathological Tau protein in cognitive impairment
Neurofibrillary tangle (NFT) formed by hyperphosphorylated Tau is considered to be one of the important reasons of cognitive… 
2019
2019
Biomarkers for Alzheimer's disease and the APOE polymorphism
Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core… 
2013
2013
APP / PS 1 MICE OVEREXPRESSING SREBP-2 EXHIBIT COMBINED A β ACCUMULATION AND TAU PATHOLOGY UNDERLYING ALZHEIMER ’ S DISEASE
Current evidence indicates that excess brain cholesterol regulates amyloid-b (Ab) deposition, which in turn can regulate… 
Review
2010
Review
2010
DHA May Prevent Age-Related Dementia 1 – 3
The risk for dementia, amajor contributor to incapacitation and institutionalization, rises rapidly asweage, doubling every 5 y… 
2001
2001
The emerging utility of animal models of chronic neurodegenerative diseases
The two most common neurodegenerative diseases are Alzheimer’s disease (AD) and Parkinson’s disease (PD). The symptoms are caused… 
1990
1990
The temporal expression of amyloid precursor protein mRNA in vitro in dissociated hippocampal neuron cultures
1989
1989
Aberrant guanosine triphosphate–beta‐tubulin interaction in Alzheimer's disease
Guanosine triphosphate (GTP) is an absolute requirement for tubulin polymerization in situ. The nucleotide photoaffinity probe 8… 
1988
1988
Partial Sequence of MAP2 in the Region of a Shared Epitope with Alzheimer Neuronbrillary Tangles
Abstract: A 3.3‐kilobase DNA complementary to human microtubule‐associated protein 2 (MAP2) was sequenced by the dideoxy method… 
1987
1987
Isolation of cDNAs coding for epitopes shared by microtubule‐associated proteins and neurofibrillary tangles in Alzheimer's disease
1986
1986
Aluminosilicates and the ageing brain: implications for the pathogenesis of Alzheimer's disease.
Senile plaques are a neuropathological feature of the ageing brain and consist of abnormal neuritic and glial processes… 
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