neurofibrillary tangle (cell component)

Known as: neurofibrillary tangle 
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
051019762018

Papers overview

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Highly Cited
2004
Highly Cited
2004
BACKGROUND Pathologic changes in the Alzheimer disease (AD) brain occur in a hierarchical neuroanatomical pattern affecting… (More)
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Highly Cited
2001
Highly Cited
2001
Human apolipoprotein (apo) E4, a major risk factor for Alzheimer's disease (AD), occurs in amyloid plaques and neurofibrillary… (More)
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Highly Cited
1999
Highly Cited
1999
One of the neuropathological hallmarks of Alzheimer's disease is the neurofibrillary tangle, which contains paired helical… (More)
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Highly Cited
1999
Highly Cited
1999
The p38 mitogen-activated protein kinase is a stress-activated enzyme responsible for transducing inflammatory signals and… (More)
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1997
1997
Microglial cells are the main component of the brain's resident immune system and are activated in Alzheimer disease (AD). We… (More)
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Highly Cited
1997
Highly Cited
1997
Activated microglia, overexpressing interleukin-1 (IL-1), and activated astrocytes, overexpressing S100beta, have been implicated… (More)
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Highly Cited
1994
Highly Cited
1994
The apolipoprotein E (apoE) type 4 allele (APOE4) is a susceptibility gene for late-onset familial and sporadic Alzheimer disease… (More)
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Highly Cited
1992
Highly Cited
1992
We report the results of an examination of the elemental content of neurofibrillary tangle-bearing and neurofibrillary tangle… (More)
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Highly Cited
1991
Highly Cited
1991
Clinical diagnosis of Parkinson's syndrome (PS) is reasonably easy in most cases but the distinction between different variants… (More)
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1991
1991
The major intracytoplasmic lesion of Alzheimer's disease is the neurofibrillary tangle (NFT), which is primarily composed of… (More)
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