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neurofibrillary tangle (cell component)

Known as: neurofibrillary tangle 
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell… Expand
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Aluminium (Al) is the most common metal and widely distributed in our environment. Al was first isolated as an element in 1827… Expand
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Highly Cited
2012
Highly Cited
2012
A growing body of evidence demonstrates an association between vascular risk factors and Alzheimer's disease. This study… Expand
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Highly Cited
2011
Highly Cited
2011
Intracytoplasmic proteinaceous inclusions, primarily composed of tau or α-synuclein (α-syn), are predominant pathological… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The progranulin gene (GRN) is mutated in 5-10% of patients with frontotemporal lobar degeneration (FTLD) and in about… Expand
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Highly Cited
2005
Highly Cited
2005
Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tauP301L)4510 mouse expresses the… Expand
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Highly Cited
2005
Highly Cited
2005
Mutations in the microtubule-associated protein tau gene have been linked to neurofibrillary tangle (NFT) formation in several… Expand
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Highly Cited
2001
Highly Cited
2001
Human apolipoprotein (apo) E4, a major risk factor for Alzheimer's disease (AD), occurs in amyloid plaques and neurofibrillary… Expand
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Highly Cited
2001
Highly Cited
2001
Abstract. Neurofibrillary tangle (NFT) formation in the CA1 region of the hippocampus is one of the early events in the… Expand
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Highly Cited
1997
Highly Cited
1997
Microglial cells are the main component of the brain's resident immune system and are activated in Alzheimer disease (AD). We… Expand
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Highly Cited
1996
Highly Cited
1996
A disturbance of the microtubule network in neurons containing neurofibrillary tangles (NFT), one of the characteristic… Expand
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