Aberrant guanosine triphosphate–beta‐tubulin interaction in Alzheimer's disease

@article{Khatoon1989AberrantGT,
  title={Aberrant guanosine triphosphate–beta‐tubulin interaction in Alzheimer's disease},
  author={S. Khatoon and S. Campbell and B. Haley and J. Slevin},
  journal={Annals of Neurology},
  year={1989},
  volume={26}
}
Guanosine triphosphate (GTP) is an absolute requirement for tubulin polymerization in situ. The nucleotide photoaffinity probe 8‐azidoguanosine 5′‐triphosphate (8N3GTP) has been shown to be a biological mimic of GRP in this system and, also, an effective active site probe of the exchangeable GRP binding site. Using [32P]8N3GTP we demonstrate that the exchangeable GTP site of the beta subunit of tubulin is available to added guanine nucleotide in normal aged brain homogenates, whereas it is… Expand
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Nucleotide photoaffinity labeling of protein kinase subunits.
  • B. Haley
  • Chemistry, Medicine
  • Methods in enzymology
  • 1991
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