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MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by targeting the mRNA of protein-coding genes for either cleavage or repression of translation. The roles of… Expand
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
- Na Xu, Thales Papagiannakopoulos, Guangjin Pan, J. Thomson, K. Kosik
- Biology, Medicine
- 15 May 2009
MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an important role in many developmental processes. We report here that expression of microRNA-145 (miR-145) is low in… Expand
The Amphimedon queenslandica genome and the evolution of animal complexity
Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from the… Expand
Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing α-synuclein and ubiquitin. Rare… Expand
A microRNA array reveals extensive regulation of microRNAs during brain development.
Several hundred microRNAs (miRNAs) have recently been cloned from a wide range of organisms across phylogeny. Despite the high degree of conservation of miRNAs, their functions in general, and in… Expand
Translocation of RNA Granules in Living Neurons
- R. B. Knowles, J. H. Sabry, +4 authors K. Kosik
- Biology, Medicine
- The Journal of Neuroscience
- 15 December 1996
Sorting of RNAs to specific subcellular loci occurs in diverse settings from fly oocytes to mammalian neurons. Using the membrane-permeable nucleic acid stain SYTO 14, we directly visualized the… Expand
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
MicroRNAs (miRNAs) are recently discovered small non-coding transcripts with a broad spectrum of functions described mostly in invertebrates. As post-transcriptional regulators of gene expression,… Expand
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.
MicroRNA dysregulation is observed in different types of cancer. MiR-21 up-regulation has been reported for the majority of cancers profiled to date; however, knowledge is limited on the mechanism of… Expand
Neuronal RNA Granules A Link between RNA Localization and Stimulation-Dependent Translation
RNA granules are a macromolecular structure observed in neurons, where they serve as motile units that translocate mRNAs. Isolated RNA granules are highly enriched in Staufen protein and… Expand
CaMKIIα 3′ Untranslated Region-Directed mRNA Translocation in Living Neurons: Visualization by GFP Linkage
The CaMKIIα mRNA extends into distal hippocampal dendrites, and the 3′ untranslated region (3′UTR) is sufficient to mediate this localization. We labeled the 3′UTR of the CaMKIIα mRNA in hippocampal… Expand