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Tau pathology in Alzheimer disease and other tauopathies.
Just as neuronal activity is essential to normal brain function, microtubule-associated protein tau appears to be critical to normal neuronal activity in the mammalian brain, especially in theExpand
Role of protein kinase B in Alzheimer's neurofibrillary pathology
Protein kinase B (PKB) is an important intermediate in the phosphatidylinositol-3 kinase signaling cascade that acts to phosphorylate glycogen synthase kinase-3 (GSK-3) at its serine 9 residue,Expand
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
Alzheimer's disease, the most common cause of dementia, is multifactorial and heterogeneous; its diagnosis remains probable. We postulated that more than one disease mechanism yielded Alzheimer'sExpand
Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.
Alzheimer disease (AD) has polyetiology. Independent of the etiology the disease is characterized histopathologically by the intraneuronal accumulation of paired helical filaments (PHF), formingExpand
Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients
Neurofilament (NF) subunits NF-H, NF-M and NF-L are hyperphosphorylated and elevated in Alzheimer disease (AD) brain. We investigated the level and phosphorylation states of NF subunits in lumbarExpand
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2 PP2A/SET
PP2A‐A physically interacts with PP2A‐B and PP2A‐C by pull down (view interaction)
Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
Microtubule associated protein tau is abnormally phosphorylated in Alzheimer disease (AD) brain. In the present study we investigated (i) whether tau is axonal or both axonal and somatodendritic,Expand
Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach.
Neurofibrillary degeneration is a key histopathological brain lesion of Alzheimer disease (AD) and related neurodegenerative disorders such as frontotemporal dementia and Parkinsonism linked toExpand
Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine.
The activity of protein phosphatase (PP)-2A, which regulates tau phosphorylation, is compromised in Alzheimer disease brain. Here we show that the transient transfection of PC12 cells withExpand
Significance and mechanism of alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion
Abnormally hyperphosphorylated tau which is the major protein subunit of paired helical filaments (PHF)/neurofibrillary tangles is the pivotal lesion in Alzheimer disease (AD) and relatedExpand
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