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Tau pathology in Alzheimer disease and other tauopathies.
Role of protein kinase B in Alzheimer's neurofibrillary pathology
The increase in PKB levels corresponded with a several-fold increase in the levels of total tau and abnormally hyperphosphorylated tau at the Tau-1 site suggest the involvement of PKB/GSK-3 signaling in Alzheimer neurofibrillary degeneration.
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
Alzheimer's disease was subdivided into at least five subgroups based on CSF levels of Aβ1‐42, tau, and ubiquitin; each subgroup presented a different clinical profile.
Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.
It is suggested that a defect in the protein phosphorylation/dephosphorylation system leads to a hyperphosphorylated tau that causes disassembly of microtubules and consequently a retrograde neuronal degeneration; that CSF tau and conjugated ubiquitin levels are promising markers of AD brain pathology.
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2 PP2A/SET
Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients
Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach.
The abnormal hyperphosphorylation of tau leads to neurodegeneration through breakdown of the microtubule network and that the abnormal tau on association with normal tau forms neurofibrillary tangles of tAU filaments.
Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine.
Novel mechanisms by which I2PP2A regulates the intracellular activity of PP2A and phosphorylation of tau are demonstrated, and by which Memantine modulates PP 2A signaling and inhibits neurofibrillary degeneration are demonstrated.
Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein
The studies indicate that the abnormal phosphorylation—not a decrease in the level of τ—is a likely cause of neurofibrillary degeneration in AD.