Neurofibrillary degeneration (morphologic abnormality)

Known as: NFT, Neurofibrillary tangles, Tangle, Neurofibrillary 
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with… (More)
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Review
2017
Review
2017
Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies to prevent and treat AD remain… (More)
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Review
2017
Review
2017
Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation of the tau protein into filamentous… (More)
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Review
2017
Review
2017
Tau is a microtubule-binding protein that is important for the stability of neuronal axons. It is normally expressed within… (More)
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Review
2017
Review
2017
Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and… (More)
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Review
2017
Review
2017
Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD… (More)
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Review
2002
Review
2002
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused… (More)
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Highly Cited
2001
Highly Cited
2001
The microtubule-binding protein tau has been implicated in the pathogenesis of Alzheimer's disease and related disorders. However… (More)
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Highly Cited
1999
Highly Cited
1999
OBJECTIVE To determine the spatiotemporal mapping of neurofibrillary degeneration (NFD) in normal aging and the different stages… (More)
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Review
1991
Review
1991
Eighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid… (More)
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