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nalmefene

Known as: nalmefene [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (4)

6-desoxy-6-methylenenaltrexoneNalmefene hydrochlorideRevexSelincro
Drug AllergyDrug OverdoseOpioid-Related DisordersRespiration Disorders

Broader (3)

NaltrexoneNarcotic Antagonistssynthetic opioids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
A Pharmacogenetic Determinant of Mu-Opioid Receptor Antagonist Effects on Alcohol Reward and Consumption: Evidence from Humanized Mice
2005
2005
Determination of nalmefene by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
Nalmefene is an opioid antagonist used in the treatment of alcoholism and opioid overdose. A highly sensitive method was… 
2004
2004
Central Opioid Receptors Differentially Regulate the Nalmefene-Induced Suppression of Ethanol- and Saccharin-Reinforced Behaviors in Alcohol-Preferring (P) Rats
The exact opioid-sensitive receptors participating in EtOH-seeking behaviors remains unclear. Previous studies have reported… 
Highly Cited
2003
Highly Cited
2003
A Clinical Laboratory Paradigm for Evaluating Medication Effects on Alcohol Consumption: Naltrexone and Nalmefene
Opiate antagonist medications have been shown to improve alcoholism treatment, but few human laboratory-based studies… 
1993
1993
A Comparison of YM-14673, U-50488H, and Nalmefene after Spinal Cord Injury in the Rat
A reproducible spinal cord injury model was used to compare the efficacy of three compounds previously shown to improve… 
Highly Cited
1990
Highly Cited
1990
Comparison of the neuroprotective effects of the N-methyl-D-aspartate antagonist MK-801 and the opiate-receptor antagonist nalmefene in experimental spinal cord ischemia.
Both N-methyl-D-aspartate (NMDA)-receptor antagonists and opiate-receptor antagonists have been shown to limit tissue damage… 
1990
1990
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors
1990
1990
Reversal of oxymorphone sedation by naloxone, nalmefene, and butorphanol.
The effects of naloxone (0.4 mg and 1.2 mg intravenously [IV]), nalmefene (0.03 mg/kg IV) and butorphanol (0.2 mg/kg IV and 0.4… 
1990
1990
Antagonism of fentanyl-induced respiratory depression with nalmefene.
Abstract We determined the ability of a new opioid antagonist, naimefene, to prevent fentanyl-induced respiratory depression in 8… 
Highly Cited
1987
Highly Cited
1987
Antagonism of endogenous opioids modulates memory processing
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