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nafazatrom

Known as: 1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2- pyrazolin-5-one, 3H-pyrazol-3-one,2,4-dihydro-5-methyl-2-(2-(2-naphthalenyloxy)ethyl), 1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2-pyrazolin-5-one 
A pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic AgentsFibrinolytic AgentsLipoxygenase InhibitorsPyrazolones

Narrower (1)

BAY-g 6575

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1987
Review
1987
Eicosanoids and susceptibility to ventricular arrhythmias during myocardial ischaemia and reperfusion.
1987
1987
Development of a system for evaluating 5-lipoxygenase inhibitors using human whole blood.
1987
1987
Lipoxygenase inhibitor nafazatrom fails to attenuate postischaemic ventricular dysfunction.
The role of lipoxygenase activation in the genesis of postischaemic myocardial dysfunction was investigated in open chest dogs… 
1987
1987
Biosynthesis, characterization and inhibition of leukotriene B4 in human whole blood.
Highly Cited
1986
Highly Cited
1986
Leukocyte recruitment in the subcutaneous sponge implant model of acute inflammation in the rat is not mediated by leukotriene B1.
1985
1985
Regulation of prostaglandin production by osteoblast-rich calvarial cells.
Review
1985
Review
1985
Arachidonic Acid Cascade and the Generation of Ischemia‐ and Reperfusion‐Induced Ventricular Arrhythmias
This article reviews the evidence we found in our study that the local generation of thromboxane and prostacyclin is one… 
Highly Cited
1984
Highly Cited
1984
The endothelium-dependent vasodilator effect of acetylcholine: characterization of the endothelial relaxing factor with inhibitors of arachidonic acid metabolism.
1984
1984
Conversion of arachidonic acid to two novel products by a cytochrome P450-dependent mixed-function oxidase in polymorphonuclear leukocytes.
1984
1984
Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors.
Activation (defined as lysosomal enzyme secretion and generation of O(2) of rat neutrophils has been measured with the use of… 
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