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Pyrazolones

Known as: Pyrazolones [Chemical/Ingredient] 
Compounds with a five-membered heterocyclic ring with two nitrogens and a keto OXYGEN. Some are inhibitors of TNF-ALPHA production.
National Institutes of Health

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4,4-dimethylpyrazolone4-vinyl-3-pyrazolidinoneCC 401L.N. 1520
In BloodPyrazolones, analgesics and antipyreticsagonistsantagonists & inhibitors

Papers overview

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2019
2019
The catalytic asymmetric synthesis of CF3-containing spiro-oxindole-pyrrolidine-pyrazolone compounds through squaramide-catalyzed 1,3-dipolar cycloaddition.
Pharmaceutically important compounds were synthesized through the organocatalytic 1,3-dipolar cycloaddition reaction. In the… 
2018
2018
DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides.
A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a… 
2017
2017
Selective cross-dehydrogenative C–O coupling of N-hydroxy compounds with pyrazolones. Introduction of the diacetyliminoxyl radical into the practice of organic synthesis
Oxidative C–O coupling of pyrazolones with N-hydroxy compounds of different classes (N-hydroxyphthalimide, N-hydroxybenzotriazole… 
2016
2016
Asymmetric chlorination of 4-substituted pyrazolones catalyzed by natural cinchona alkaloid.
A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a… 
2008
2008
High speed synthesis of pyrazolones using microwave-assisted neat reaction technology
Descrevemos uma sintese rapida e pratica de pirazolonas, na ausencia de solvente, sob irradiacao de microondas. Esta metodologia… 
2001
2001
Quantitative analysis of analgoantipyretics in dosage form using planar chromatography.
1995
1995
Studies on new acidic azoles as glucose-lowering agents in obese, diabetic db/db mice.
Bioisosteric substitution was used as a tool to generate several new structural alternatives to the thiazolidine-2,4-dione and… 
Review
1983
Review
1983
Hematologic effects of antipyretic analgesics. Drug-induced agranulocytosis.
1983
1983
Prostaglandins and the mode of action of antipyretic analgesic drugs.
Review
1967
Review
1967
Biochemical properties of anti-inflammatory drugs. IX. Uncoupling of oxidative phosphorylation and inhibition of a thiol enzyme (papain) by some cyclic beta-diones and ninhydrin.
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