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Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup
The QT interval.
Current state of Alzheimer’s fluid biomarkers
Some of the pathological mechanisms implicated in the sporadic AD are summarized and the data for several established and novel fluid biomarkers associated with each mechanism are highlighted.
Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty.
Data support the hypothesis that CABG surgery is associated with a reduced neuronal reserve in an aging population and suggest that patients undergoing CABg surgery were at increased risk for the emergence of AD than those undergoing PTCA.
Reversal of scopolamine-induced deficits with a single dose of donepezil, an acetylcholinesterase inhibitor
Safety and Pharmacology of a Single Intravenous Dose of Ponezumab in Subjects With Mild-to-Moderate Alzheimer Disease: A Phase I, Randomized, Placebo-Controlled, Double-Blind, Dose-Escalation Study
A 2-hour infusion of 0.1 to 10 mg/kg ponezumab was well tolerated in subjects with mild-to-moderate AD, suggesting that intravenous poneZumab alters central A&bgr; levels.
Stroke: Working Toward a Prioritized World Agenda
The Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke by using a “Brain Health” concept that enables promotion of preventive measures.
Nafazatrom‐Induced Salvage of Ischemic Myocardium in Anesthetized Dogs is Mediated through Inhibition of Neutrophil Function
Measurements of the neutrophil-specific myeloperoxidase enzyme in ischemic myocardium indicate that the smaller infarct size in dogs treated with nafazatrom is accompanied by diminished leukocyte infiltration, suggesting the ability of nafzatrom to inhibit neutrophIL function in vitro and cell infiltration in vivo may underly its myocardial-protective effects.
Report of the task force on designing clinical trials in early (predementia) AD
An international task force of individuals from academia, industry, nonprofit foundations, and regulatory agencies met to discuss optimal trial design in early (predementia) AD, and general consensus was reached on key principles involving the scope of the AD diagnosis, the selection of subjects for trials, outcome measures, and analytical methods.
Iatrogenic risk factors for Alzheimer's disease: surgery and anesthesia.
Clinical studies investigating the prevalence of POCD and dementia following surgery do not show an association with the type of anesthesia or duration of surgery, and animal studies suggest that prolonged exposure to some volatile-inhalational anesthetics increase production of amyloid-β and vulnerability to neurodegeneration, but these results are weakened by the absence of clinical support.