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mycobactin

National Institutes of Health

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mycobactins

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Highly Cited
2013
Highly Cited
2013
Disruption of mycobactin biosynthesis leads to attenuation of Mycobacterium tuberculosis for growth and virulence.
BACKGROUND  Low iron availability in the host upregulates the mbt gene cluster of Mycobacterium tuberculosis, which is… Expand
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Highly Cited
2012
Highly Cited
2012
Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis
ABSTRACT The production of mycobactin (MBT) by Mycobacterium tuberculosis is essential for this bacterium to access iron when it… Expand
Highly Cited
2011
Highly Cited
2011
Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria.
Although the antimalarial agent artemisinin itself is not active against tuberculosis, conjugation to a mycobacterial-specific… Expand
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Highly Cited
2009
Highly Cited
2009
Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for… Expand
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Review
2007
Review
2007
Siderophore-Based Iron Acquisition and Pathogen Control
SUMMARY High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority of pathogenic and… Expand
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Highly Cited
2005
Highly Cited
2005
Mycobactin-mediated iron acquisition within macrophages
Restricting the availability of iron is an important strategy for defense against bacterial infection1,2,3. Mycobacterium… Expand
Review
2004
Review
2004
Iron, mycobacteria and tuberculosis.
The role of iron in the growth and metabolism of M. tuberculosis and other mycobacteria is discussed in relation to the… Expand
Highly Cited
2000
Highly Cited
2000
The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages.
Mycobacterium tuberculosis is an important pathogen of mammals that relies on 2-hydroxyphenyloxazoline-containing siderophore… Expand
Highly Cited
1998
Highly Cited
1998
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.
BACKGROUND Many pathogenic bacteria secrete iron-chelating siderophores as virulence factors in the iron-limiting environments of… Expand
Highly Cited
1990
Highly Cited
1990
Numerical taxonomy of mycobactin-dependent mycobacteria, emended description of Mycobacterium avium, and description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp…
We performed a numerical taxonomy analysis of 38 Mycobacterium paratuberculosis and related mycobacterial strains, including wood… Expand
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