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Iron metabolism in pathogenic bacteria.
TLDR
The biochemistry of the bacterial cell can accommodate the challenges from the host and agents that interfere with bacterial iron metabolism may prove extremely valuable for chemotherapy of diseases.
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Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production.
  • C. Ratledge
  • Biology, Engineering
    Biochimie
  • 1 November 2004
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The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms.
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Regulation of lipid accumulation in oleaginous micro-organisms.
  • C. Ratledge
  • Biology
    Biochemical Society transactions
  • 1 November 2002
TLDR
The biochemistry of lipid accumulation has been investigated in yeasts and filamentous fungi and can now be described in some detail and it is proposed that ME is physically attached to FAS as part of the lipogenic metabolon.
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Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulation.
TLDR
Increased expression of the ME gene leads to both increased biosynthesis of fatty acids and formation of unsaturated fatty acids, including gamma-linolenic acid, and the hypothesis that the rate-limiting step of fatty acid biosynthesis is therefore the supply of NADPH, as generated specifically and solely by ME is considerably strengthened.
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The role of malic enzyme as the provider of NADPH in oleaginous microorganisms: a reappraisal and unsolved problems
TLDR
Stoichiometries are given for the conversion of glucose to triacylglycerols involving ME with and without the reactions of the pentose phosphate pathway (PPP) as an additional source of NADPH.
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Microbial and algal oils: Do they have a future for biodiesel or as commodity oils?
TLDR
It is concluded that yeast oils, the cheapest of the oils producible by heterotrophic microorganisms, are too expensive to be viable alternatives to the major commodity plant oils.
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Salicylic acid is not a bacterial siderophore: a theoretical study
TLDR
For microorganisms grown either in vitro or in vivo, salicylate is unlikely to function as a iron solubilizing agent and the same conclusions may also apply to 2,3-dihydroxybenzoic acid.
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Iron, mycobacteria and tuberculosis.
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A comparison of the oleaginous yeast,Candida curvata, grown on different carbon sources in continuous and batch culture
TLDR
The oleaginous yeast,Candida curvata D, was grown in both batch and continuous culture on 5 different carbon sources to compare the efficiency of fat production from the various substrates to find the highest biomass and lipid yields were attained.
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