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moxonidine

Known as: 4-Chloro-5-(2-Imidazolidinyldeneamino)-6-Methoxy-2-Methylpyrimidine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine, moxonidin 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Antihypertensive AgentsImidazoles

Narrower (3)

CyntLY-326869Zint

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2003
Review
2003
Antiadrenergic therapy of chronic heart failure: surprises and new opportunities.
The great British-American scientist-philosopher Alfred North Whitehead divided progress into three stages, the second of which… 
Review
2002
Review
2002
Imidazoline antihypertensive drugs: a critical review on their mechanism of action.
Highly Cited
2001
Highly Cited
2001
Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine.
We present a mechanism for agonist-promoted alpha(2A)-adrenergic receptor (alpha(2A)-AR) activation based on structural… 
Highly Cited
1999
Highly Cited
1999
Moxonidine improves insulin sensitivity in insulin-resistant hypertensives.
OBJECTIVE To study whether insulin sensitivity and insulin response are altered by moxonidine treatment in obese patients with… 
Highly Cited
1998
Highly Cited
1998
Assumption Testing in Population Pharmacokinetic Models: Illustrated with an Analysis of Moxonidine Data from Congestive Heart Failure Patients
Deriving a population pharmacokinetic model from real data is always associated with numerous assumptions. Violations of these… 
Highly Cited
1996
Highly Cited
1996
Endogenous monoamines inhibit glutamate transmission in the spinal trigeminal nucleus of the guinea‐pig.
1. With the use of whole‐cell patch clamp recordings in slices of guinea‐pig substantia gelatinosa (SG), we studied the serotonin… 
Highly Cited
1996
Highly Cited
1996
Effect of ramipril, nifedipine, and moxonidine on glomerular morphology and podocyte structure in experimental renal failure.
BACKGROUND Experimental renal failure causes structural alterations of the kidney. It is still unresolved how these changes are… 
Highly Cited
1995
Highly Cited
1995
Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys.
Noradrenergic involvement in the discriminative stimulus (DS) effects of cocaine was investigated in squirrel monkeys by using a… 
Highly Cited
1994
Highly Cited
1994
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla.
The rostral ventrolateral medulla (RVLM) is the primary region maintaining vasomotor tone, and a site of action for central… 
Highly Cited
1993
Highly Cited
1993
Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites.
Both the hypotension and the sedation elicited by centrally acting antihypertensive agents are traditionally attributed to… 
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