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Paraventricular oxytocin neurons are involved in neural modulation of breathing.
TLDR
Data indicate that oxytocin participates in the regulation of respiratory and cardiovascular activity, partly via projections to the rostral ventrolateral medullary (RVLM) region and phrenic nuclei.
Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.
TLDR
It is shown that disruption of the Nfia gene causes perinatal lethality, with >95% of homozygous N fia(-/-) animals dying within 2 weeks after birth.
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla.
TLDR
Moxonidine is a centrally acting antihypertensive with a selective action on I1-imidazoline receptors in RVLM and Pharmacokinetic studies showed that at the peak vasodepressor response (8 min post-injection), [3H]mox onidine spread less than 1 mm from the injection site.
Nitric oxide in the sensory function of the carotid body
TLDR
Chemosensory activity in vitro increased in a dose-dependent manner in response to L-omega-nitro arginine (L-NNA), an inhibitor of NOS activity, implying that endogenous NO is inhibitory to carotid body sensory activity.
Orexin stimulates breathing via medullary and spinal pathways.
TLDR
Data indicate that orexin regulates respiratory activity and may have a role in the pathophysiology of sleep-related respiratory disorders.
An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness.
TLDR
Data indicate that IL-5 and eosinophils are required for the induction of AHR by filarial helminths, and that mice immunized with killed B. malayi in IL- 5(-/-) mice failed to show AHR in response to cholinergic agonists.
Increased vasopressin transmission from the paraventricular nucleus to the rostral medulla augments cardiorespiratory outflow in chronic intermittent hypoxia‐conditioned rats
TLDR
It is shown that AVP released by a subset of PVN neurons modulates cardiorespiratory output via V1A receptors in the RVLM and rVRC, and increased SNA in CIH‐conditioned animals depends on up‐regulation of V1a receptors inThe RVLM.
CNS innervation of vagal preganglionic neurons controlling peripheral airways: a transneuronal labeling study using pseudorabies virus.
TLDR
The CNS cell groups that project to vagal preganglionic neurons which innervate the most distal part of the airways were identified by the viral retrograde transneuronal labeling method and were controlled by networks of lower brainstem and suprapontine neurons that lie in the same regions known to be involved in central regulation of autonomic functions.
Effect of Pseudomonas infection on weight loss, lung mechanics, and cytokines in mice.
TLDR
Results suggest that weight loss in P. aeruginosa-infected mice was associated with the inflammatory process and not with altered pulmonary responsiveness, which may provide insights into the cause of cachexia and weight loss seen in patients with CF.
Brain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses.
TLDR
A better understanding of these normal and altered central neural circuits and mechanisms could potentially improve the design of therapeutic interventions and the treatment of airway obstructive diseases.
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