Phenylpropanolamine Constricts Mouse and Human Blood Vessels by Preferentially Activating α2-Adrenoceptors

  title={Phenylpropanolamine Constricts Mouse and Human Blood Vessels by Preferentially Activating $\alpha$2-Adrenoceptors},
  author={Nicholas A Flavahan},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={432 - 439}
  • N. Flavahan
  • Published 1 April 2005
  • Biology, Medicine, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
Phenylpropanolamine (dl-norephedrine) was one of the most widely used therapeutic agents to act on the sympathetic nervous system. Because of concerns regarding incidents of stroke, its use as a nasal decongestant was discontinued. Although considered an α1-adrenergic agonist, the vascular adrenergic pharmacology of phenylpropanolamine was not fully characterized. Unlike most other circulations, the vasculature of the nasal mucosa is highly enriched with constrictor α2-adrenoceptors. Therefore… 

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