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G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an autosomal recessive form of this disorder to chromosome 13q14.11–13q21.33, and identified homozygous truncatingExpand
Direct inhibition by cannabinoids of human 5‐HT3A receptors: probable involvement of an allosteric modulatory site
Excised outside‐out patches from HEK293 cells stably transfected with the human (h) 5‐HT3A receptor cDNA were used to determine the effects of cannabinoid receptor ligands on the 5‐HT‐induced currentExpand
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors
Human cerebral cortical slices and synaptosomes, guinea-pig cerebral cortical slices and human right atrial appendages were used to study the effects of SB-216641, a preferential h5-HT1B receptorExpand
[Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options].
In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The readerExpand
Agmatine (decarboxylated L-arginine): physiological role and therapeutic potential.
Agmatine, a cationic amine formed by decarboxylation of l-arginine by the mitochondrial enzyme arginine decarboxylase (ADC), is widely but unevenly distributed in mammalian tissues. Agmatine in theExpand
Agmatine: clinical applications after 100 years in translation.
Agmatine (decarboxylated arginine) has been known as a natural product for over 100 years, but its biosynthesis in humans was left unexplored owing to long-standing controversy. Only recently has theExpand
Presynaptic Imidazoline Receptors: New Developments in Characterization and Classification a
ABSTRACT: Presynaptic imidazoline receptors (IRs) which inhibit norepinephrine (NE) release from sympathetic nerve endings have been identified in cardiovascular tissue of man, rabbit, rat, andExpand
A re-investigation of questionable subclassifications of presynaptic α2-autoreceptors: rat vena cava, rat atria, human kidney and guinea-pig urethra
Abstract It has been suggested that at least the majority of mammalian presynaptic α2-autoreceptors belong to the genetic α2A/D-adrenoceptor subtype. The aim of the present study was to re-examineExpand
Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein via presynaptic 5-HT receptors similar to the 5-HT1D subtype
SummaryThe human saphenous vein preincubated with [3H]noradrenaline was used to determine the pharmacological properties of the release-inhibiting presynaptic serotonin (5-HT) receptor on theExpand
Dual interaction of agmatine with the rat α2D‐adrenoceptor: competitive antagonism and allosteric activation
In segments of rat vena cava preincubated with [3H]‐noradrenaline and superfused with physiological salt solution, the influence of agmatine on the electrically evoked [3H]‐noradrenaline release, theExpand
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