monophosphoryl lipid A

Known as: MPLA, 3-O-Desacyl-4'-Monophosphoryl Lipid A, 3-Deacylated Monophosphoryl Lipid A 
A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4… (More)
National Institutes of Health

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Topic mentions per year

1984-2018
0204019842018

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Highly Cited
2013
Highly Cited
2013
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The pathogenesis of this neurodegenerative disease… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Two previous studies of a herpes simplex virus type 2 (HSV-2) subunit vaccine containing glycoprotein D in HSV… (More)
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2009
2009
TLR4 stimulation by lipopolysaccharide can cause both MAL/MyD88- and TRAM/TRIF (Toll IL-1 receptor domain-containing adaptor… (More)
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Highly Cited
2007
Highly Cited
2007
The inflammatory toxicity of lipopolysaccharide (LPS), a component of bacterial cell walls, is driven by the adaptor proteins… (More)
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2005
2005
BACKGROUND Monophosphoryl lipid A (MPL) is a nontoxic derivative of the lipopolysaccharide (LPS) of Salmonella minnesota R595… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Allergen-specific immunotherapy represents a causal form of treatment for IgE-mediated allergies. The allergen extract… (More)
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Highly Cited
2003
Highly Cited
2003
Monophosphoryl lipid A (MPL) is a nontoxic derivative of lipopolysaccharide (LPS) that exhibits adjuvant properties similar to… (More)
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Highly Cited
2002
Highly Cited
2002
The induction of dendritic cell (DC) maturation is critical for the induction of Ag-specific T lymphocyte responses and may be… (More)
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2000
2000
The induction of immune responses in vivo is typically performed with antigens administered in external adjuvants, like alum… (More)
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1997
1997
Monophosphoryl lipid A (MPL) is a nontoxic derivative of the lipid A region of lipopolysaccharide (LPS) that is being developed… (More)
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