Skip to search formSkip to main contentSkip to account menu

monophosphoryl lipid A

Known as: MPLA, 3-O-Desacyl-4'-Monophosphoryl Lipid A, 3-Deacylated Monophosphoryl Lipid A 
A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

CRX-675

Broader (2)

Immunologic AdjuvantsLipid A
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.
Frameshift mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and myelofibrosis… 
Highly Cited
2011
Highly Cited
2011
Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery.
Review
2009
Review
2009
Adjuvants and autoimmunity
Some adjuvants may exert adverse effects upon injection or, on the other hand, may not trigger a full immunological reaction. The… 
Highly Cited
2003
Highly Cited
2003
Allergen‐specific immunotherapy with a monophosphoryl lipid A‐adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy…
Background Allergen‐specific immunotherapy represents a causal form of treatment for IgE‐mediated allergies. The allergen extract… 
Highly Cited
2003
Highly Cited
2003
Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report.
Highly Cited
2002
Highly Cited
2002
Monophosphoryl Lipid A Activates Both Human Dendritic Cells and T Cells1
The induction of dendritic cell (DC) maturation is critical for the induction of Ag-specific T lymphocyte responses and may be… 
Highly Cited
2001
Highly Cited
2001
A well‐tolerated grass pollen‐specific allergy vaccine containing
a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections
Background: We present data showing that a Th1‐inducing adjuvant can reduce the number of injections required for allergy… 
Review
1999
Review
1999
Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines.
Many of the latest trends in vaccine development are dependent on immunological adjuvants that mediate and promote a wide variety… 
Review
1995
Review
1995
Monophosphoryl Lipid A as an Adjuvant
The increasing threat to the human population posed by new or resurgent infectious diseases, coupled with an alarming rise in the… 
Review
1993
Review
1993
Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)