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mofezolac

Known as: (3,4-bis(4-methoxyphenyl)-5-isoxazolyl)acetic acid, (3,4-di-(4-methoxyphenyl)-5-isoxazolyl)acetic acid, 3,4-DMPIAA 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclooxygenase InhibitorsIsoxazoles

Narrower (1)

N 22 compound

Papers overview

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Highly Cited
2004
Highly Cited
2004
Combined effects of cyclooxygenase‐1 and cyclooxygenase‐2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice
As with cyclooxygenase (COX)‐2, genetic disruption of COX‐1 gene or pharmacologic inhibition of its activity has been shown to… 
2004
2004
Constitutive Expression and Involvement of Cyclooxygenase-2 in Human Megakaryocytopoiesis
Objective—Cyclooxygenase-1 (COX-1), but not COX-2, is expressed in human platelets, and thromboxane A2 (TXA2) produced via COX-1… 
2004
2004
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients
AbstractObjective and design:The aim of this study was to confirm the involvement of cyclooxygenase (COX)-1 in rheumatoid… 
2002
2002
Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension.
COX-2 is an inducible cyclooxygenase (COX) that has been reported to be expressed in the macula densa and surrounding cortical… 
2002
2002
Role of kinin and prostaglandin in cutaneous thermal nociception.
1998
1998
Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
1998
1998
Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.
1997
1997
Principal involvement of cyclooxygenase-1-derived prostaglandins in the c-fos expression of the rat hind brain following visceral stimulation with acetic acid.
1990
1990
[Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].
Pharmacological activities of mofezolac were investigated in experimental animal models and compared with those of indomethacin… 
1990
1990
[Three-month subacute oral toxicity study of mofezolac (N-22) in dogs].
Mofezolac (N-22) is a new developed analgesic and anti-inflammatory agent. A subacute oral toxicity test of N-22 was carried out… 
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