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mofezolac

Known as: (3,4-bis(4-methoxyphenyl)-5-isoxazolyl)acetic acid, (3,4-di-(4-methoxyphenyl)-5-isoxazolyl)acetic acid, 3,4-DMPIAA 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclooxygenase InhibitorsIsoxazoles

Narrower (1)

N 22 compound

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile.
Highly Cited
2008
Highly Cited
2008
Role of interleukin-1β and tumor necrosis factor-α-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice
Highly Cited
2004
Highly Cited
2004
Combined effects of cyclooxygenase‐1 and cyclooxygenase‐2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice
As with cyclooxygenase (COX)‐2, genetic disruption of COX‐1 gene or pharmacologic inhibition of its activity has been shown to… 
2004
2004
Constitutive Expression and Involvement of Cyclooxygenase-2 in Human Megakaryocytopoiesis
Objective—Cyclooxygenase-1 (COX-1), but not COX-2, is expressed in human platelets, and thromboxane A2 (TXA2) produced via COX-1… 
Highly Cited
2002
Highly Cited
2002
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
Cyclooxygenase (COX)-2, one enzyme isoform responsible for producing prostanoids from arachidonic acid, contributes to colon… 
2002
2002
Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension.
COX-2 is an inducible cyclooxygenase (COX) that has been reported to be expressed in the macula densa and surrounding cortical… 
Highly Cited
1998
Highly Cited
1998
Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells.
1998
1998
Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
1997
1997
Principal involvement of cyclooxygenase-1-derived prostaglandins in the c-fos expression of the rat hind brain following visceral stimulation with acetic acid.
1990
1990
[Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].
Pharmacological activities of mofezolac were investigated in experimental animal models and compared with those of indomethacin… 
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