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mofezolac

Known as: (3,4-bis(4-methoxyphenyl)-5-isoxazolyl)acetic acid, (3,4-di-(4-methoxyphenyl)-5-isoxazolyl)acetic acid, 3,4-DMPIAA 
National Institutes of Health

Papers overview

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2017
2017
The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we… Expand
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2017
2017
Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to… Expand
Highly Cited
2008
Highly Cited
2008
The present study investigated whether the endogenous pro-inflammatory cytokines [interleukin (IL)-1beta and tumor necrosis… Expand
2006
2006
We demonstrated recently that mofezolac, a cyclooxygenase‐1 (COX‐1) selective inhibitor, suppresses the development of… Expand
Highly Cited
2004
Highly Cited
2004
As with cyclooxygenase (COX)‐2, genetic disruption of COX‐1 gene or pharmacologic inhibition of its activity has been shown to… Expand
Highly Cited
2003
Highly Cited
2003
Nonsteroidal anti-inflammatory drugs are known to suppress the occurrence and progression of malignancies such as colorectal… Expand
Highly Cited
2002
Highly Cited
2002
Cyclooxygenase (COX)-2, one enzyme isoform responsible for producing prostanoids from arachidonic acid, contributes to colon… Expand
Highly Cited
1999
Highly Cited
1999
We previously reported the induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs (NSAIDs) in cultured… Expand
1998
1998
The oral administration of mofezolac, [3,4-di(4-methoxyphenyl)-5-isoxazolyl]acetic acid, resulted in the suppression of writhing… Expand
Highly Cited
1998
Highly Cited
1998
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to cause apoptosis in several cell lines including transformed… Expand