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Claudin-based tight junctions are crucial for the mammalian epidermal barrier
TLDR
Findings provide the first evidence that continuous claudin-based TJs occur in the epidermis and that these TJs are crucial for the barrier function of the mammalian skin.
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.
TLDR
Results indicate that Flt-1 without tyrosine kinase domain is sufficient to allow embryonic development with normal angiogenesis, and that a receptor tyrosin kinase plays a main biological role as a ligand-binding molecule.
Complex phenotype of mice lacking occludin, a component of tight junction strands.
TLDR
The generation and analysis of mice carrying a null mutation in the occludin gene suggested that the functions of TJs as well as occlUDin are more complex than previously supposed.
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
TLDR
It is shown that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system via its receptor AdipoR1 to stimulate food intake.
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
TLDR
It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.
Altered microtubule organization in small-calibre axons of mice lacking tau protein
TLDR
The results argue against the suggested role of tau in axonal elongation but confirm that it is crucial in the stabilization and organization of axonal microtubules in a certain type of axon.
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.
TLDR
A mouse model of FAP was created that circumvents the embryonic lethality of Apc deficiency and directs Apc inactivation specifically to the colorectal epithelium.
Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene
TLDR
It is found that homozygous loss of the PrP gene has no deleterious effect on the development of these mice and renders them resistant to prion2, suggesting that PrP plays a role in the long-term survival of Purkinje neurons.
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation*
TLDR
This study provides the first direct evidence that adiponectin plays a protective role against insulin resistance and atherosclerosis in vivo.
Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
TLDR
This universal and quantitative EMT scoring was used to establish an EMT spectrum across various cancers, with good correlation noted between cell lines and tumours, and it is demonstrated that mesenchymal‐like tumours do not always show resistance to chemotherapy.
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