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Claudin-based tight junctions are crucial for the mammalian epidermal barrier
The tight junction (TJ) and its adhesion molecules, claudins, are responsible for the barrier function of simple epithelia, but TJs have not been thought to play an important role in the barrierExpand
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ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Apoptosis signal‐regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H2O2, and activates c‐Jun NH2‐terminalExpand
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Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.
Receptor tyrosine kinases Flt-1 and Flk-1/KDR, and their ligand, the vascular endothelial growth factor (VEGF), were shown to be essential for angiogenesis in the mouse embryo by gene targeting.Expand
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Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The effects ofExpand
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Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.
Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene. With theExpand
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RNA-binding protein Musashi family: Roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation
Homologues of the Musashi family of RNA-binding proteins are evolutionarily conserved across species. In mammals, two members of this family, Musashi1 (Msi1) and Musashi2 (Msi2), are stronglyExpand
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Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells.
It has been reported that PTH exerts bone-forming effects in vivo when administered intermittently. In the present study, the anabolic effects of PTH(1-34) on osteoblast differentiation were examinedExpand
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Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation*
The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, and it has been reported to exhibit putativeExpand
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Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
STAT3 regulates glucose homeostasis by suppressing the expression of gluconeogenic genes in the liver. The mechanism by which hepatic STAT3 is regulated by nutritional or hormonal status has remainedExpand
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Lack of acrosome formation in mice lacking a Golgi protein, GOPC
  • R. Yao, C. Ito, +7 authors T. Noda
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 30 July 2002
The acrosome is a unique organelle that plays an important role at the site of sperm–zona pellucida binding during the fertilization process, and is lost in globozoospermia, an inherited infertilityExpand
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