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mitosene

 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Mitomycin C (MMC) is a chemotherapeutic drug that requires an enzymatic bioreduction to exert its biological effects. Upon… Expand
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Highly Cited
2006
Highly Cited
2006
[reaction: see text] Only 1-3 mol % of PtCl(2) or AuBr(3) was sufficient to promote generation and [3+2] cycloaddition of… Expand
1997
1997
BACKGROUND The class of antitumor antibiotics that includes FR900482 has a very close structural analogy to the mitomycins, one… Expand
1993
1993
The reductive activation of mitosene compounds was studied with cyclic voltammetry and HPLC analysis. Reduction of mitosenes… Expand
Highly Cited
1992
Highly Cited
1992
The role of DT-diaphorase (DTD, EC 1.6.99.2) in the bioreductive activation of mitomycin C was examined using purified rat… Expand
Highly Cited
1992
Highly Cited
1992
A new covalent mitomycin C-DNA adduct (4) was isolated from DNA exposed to reductively activated mitomycin C (MC) in vitro. The… Expand
Highly Cited
1989
Highly Cited
1989
Mitosenes of both the pyrrolo- and pyrido[1,2-a]indole type have been prepared via modification of these heterotricyclic… Expand
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Highly Cited
1988
Highly Cited
1988
Mitomycin C, an antitumor antibiotic, is known to require reductive activation in order to function as an alkylating agent. In… Expand
1981
1981
A series of 1-substituted mitosene analogues of the mitomycin antitumor antibiotics was prepared by total synthesis and screened… Expand