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mitosene

 
National Institutes of Health

Papers overview

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2014
2014
A DNA crosslinking approach, which is distinct but related to the double alkylation by mitomycin C, involving a novel… Expand
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2012
2012
Mitomycin C (MMC) is a chemotherapeutic drug that requires an enzymatic bioreduction to exert its biological effects. Upon… Expand
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2010
2010
The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53-independent cell death pathway than… Expand
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2008
2008
The cancer chemotherapeutic agent mitomycin C (MC) alkylates and cross-links DNA monofunctionally and bifunctionally in vivo and… Expand
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Highly Cited
1992
Highly Cited
1992
The role of DT-diaphorase (DTD, EC 1.6.99.2) in the bioreductive activation of mitomycin C was examined using purified rat… Expand
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1992
1992
A new covalent mitomycin C-DNA adduct (4) was isolated from DNA exposed to reductively activated mitomycin C (MC) in vitro. The… Expand
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1992
1992
The antitumour activity of a series of mitosene compounds in various in vitro tumour models was evaluated in terms of physico… Expand
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1989
1989
Mitosenes of both the pyrrolo- and pyrido[1,2-a]indole type have been prepared via modification of these heterotricyclic… Expand
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1988
1988
Mitomycin C, an antitumor antibiotic, is known to require reductive activation in order to function as an alkylating agent. In… Expand
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1986
1986
After anaerobic reductive activation by either NADPH cytochrome P-450 reductase (EC 1.6.2.4) or xanthine oxidase (EC 1.2.3.2… Expand
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