mitosene

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1971-2016
012319712016

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2014
2014
A DNA crosslinking approach, which is distinct but related to the double alkylation by mitomycin C, involving a novel… (More)
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2008
2008
The cancer chemotherapeutic agent mitomycin C (MC) alkylates and cross-links DNA monofunctionally and bifunctionally in vivo and… (More)
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1997
1997
BACKGROUND The class of antitumor antibiotics that includes FR900482 has a very close structural analogy to the mitomycins, one… (More)
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1993
1993
The reductive activation of mitosene compounds was studied with cyclic voltammetry and HPLC analysis. Reduction of mitosenes… (More)
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1992
1992
The antitumour activity of a series of mitosene compounds in various in vitro tumour models was evaluated in terms of physico… (More)
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1992
1992
The role of DT-diaphorase (DTD, EC 1.6.99.2) in the bioreductive activation of mitomycin C was examined using purified rat… (More)
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1992
1992
A new covalent mitomycin C-DNA adduct (4) was isolated from DNA exposed to reductively activated mitomycin C (MC) in vitro. The… (More)
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1989
1989
Mitosenes of both the pyrrolo- and pyrido[1,2-a]indole type have been prepared via modification of these heterotricyclic… (More)
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1988
1988
Mitomycin C, an antitumor antibiotic, is known to require reductive activation in order to function as an alkylating agent. In… (More)
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1986
1986
After anaerobic reductive activation by either NADPH cytochrome P-450 reductase (EC 1.6.2.4) or xanthine oxidase (EC 1.2.3.2… (More)
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