mipomersen
National Institutes of Health
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Lipoprotein(a) [Lp(a)], a low‐density lipoprotein (LDL)‐like particle, has been independently associated with increased…
INTRODUCTION
The familial hypercholesterolemias (FH) are a group of undertreated genetically inherited disorders of lipid…
Hepatitis C virus (HCV), a positive-stranded RNA flavivirus, persistently infects approximately 170 million persons worldwide and…
Mipomersen, an antisense oligonucleotide that reduces hepatic production of apoB, has been shown in phase 2 studies to decrease…
Antisense therapy has generated waves of enthusiasm and disappointment. With a new drug about to be submitted for approval, is it…
Mipomersen, an antisense oligonucleotide directed against apolipoprotein B-100 (apoB), was investigated for its safety and…
volume 28 number 4 april 2010 nature biotechnology The news was not all positive, however. Elevated liver enzymes were observed…
Nat. Biotechnol. 28, 295–297 (2010); published online 8 April 2010; corrected after print 9 July 2010 In the version of this…