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merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

NSC 336628

Broader (2)

ThiobarbituratesTopoisomerase II Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase IIα Inhibitors
After the identification of a new lead bisphenol compound that had good topoisomerase IIα (EC 5.99.1.3) inhibitory activity, a… 
2006
2006
A Three-Dimensional Quantitative Structure-Activity Relationship Study of the Inhibition of the ATPase Activity and the Strand Passing Catalytic Activity of Topoisomerase IIα by Substituted Purine…
Based on the topoisomerase IIα catalytic inhibitory activity of a previous hit compound, NSC35866, we screened 40 substituted… 
2004
2004
NMR structural studies reveal a novel protein fold for MerB, the organomercurial lyase involved in the bacterial mercury resistance system.
Mercury resistant bacteria have developed a system of two enzymes (MerA and MerB), which allows them to efficiently detoxify both… 
Review
2004
Review
2004
Merbarone: an antitumor agent entering clinical trials
SummaryMerbarone was developed to clinical trial stage on the basis of its ‘curative’ activity against P388 and L1210 leukemias… 
Review
1999
Review
1999
Bacterial detoxification of Hg(II) and organomercurials.
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… 
Highly Cited
1997
Highly Cited
1997
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: Cell cycle arrest and induction of aneuploidy
In order to clarify possible risks of aneuploidy induction in germ cells by cancer chemotherapy we studied effects of a non… 
1997
1997
Phase II trial of merbarone in patients with malignant brain tumors
The standard treatment for patients with primary malignant glioma includes surgical resection, radiotherapy, and nitrosourea… 
1995
1995
Inhibitors of topoisomerase II delay progress through mitosis and induce a doubling of the DNA content in CHO cells.
The effect of inhibition of topoisomerase II on chromosome segregation in CHO cells has been studied using cytogenetical… 
1985
1985
5-(N-phenylcarboxamido)-2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent.
1982
1982
Methionine enkephalinergic neuronal activity in cerebral nuclei of spontaneously hypertensive rats.
The role of methionine enkephalin (ME) neurons in the development of genetic hypertension in SHR is the subject of this study… 
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