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merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… 
National Institutes of Health

Papers overview

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2008
2008
After the identification of a new lead bisphenol compound that had good topoisomerase IIα (EC 5.99.1.3) inhibitory activity, a… 
2004
2004
Mercury resistant bacteria have developed a system of two enzymes (MerA and MerB), which allows them to efficiently detoxify both… 
Review
2004
Review
2004
SummaryMerbarone was developed to clinical trial stage on the basis of its ‘curative’ activity against P388 and L1210 leukemias… 
Review
1999
Review
1999
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… 
Highly Cited
1997
Highly Cited
1997
In order to clarify possible risks of aneuploidy induction in germ cells by cancer chemotherapy we studied effects of a non… 
1997
1997
The standard treatment for patients with primary malignant glioma includes surgical resection, radiotherapy, and nitrosourea… 
1995
1995
The effect of inhibition of topoisomerase II on chromosome segregation in CHO cells has been studied using cytogenetical… 
1982
1982
The role of methionine enkephalin (ME) neurons in the development of genetic hypertension in SHR is the subject of this study…