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The curious phenomenon of similar levels of methylmercury (MeHg) accumulation in fish from contaminated and pristine environments… Expand The nuclear enzyme DNA topoisomerase II is a major target for antineoplastic agents. All topoisomerase II-directed agents are… Expand Merbarone (5-[N-phenyl carboxamido]-2-thiobarbituric acid) is an anticancer drug that inhibits the catalytic activity of DNA… Expand The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… Expand Merbarone is a catalytic inhibitor of topoisomerase II that is in clinical trials as an anticancer agent. Despite the potential… Expand BACKGROUND
Patients with metastatic (stage IV) non-small-cell lung cancer usually have a poor prognosis and disease refractory to… Expand Several recently developed derivatives of bis(2,6-dioxopiperazine) have been shown to be new antitumor agents and are currently… Expand Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer… Expand A 13.5-kilobase HindIII fragment, bearing an intact mercury resistance (mer) operon, was isolated from chromosomal DNA of broad… Expand The p170 and p180 forms of topoisomerase II have been compared. The concentration dependence of ATP for catalytic activity of the… Expand