merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… (More)
National Institutes of Health

Papers overview

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2003
2003
Methylmercury is an environmental pollutant that biomagnifies in the aquatic food chain with severe consequences for humans and… (More)
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2002
2002
Merbarone is a catalytic inhibitor of topoisomerase II (topo II) that has been proposed to act primarily by blocking topo II… (More)
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Review
1999
Review
1999
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… (More)
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Highly Cited
1998
Highly Cited
1998
Merbarone is a catalytic inhibitor of topoisomerase II that is in clinical trials as an anticancer agent. Despite the potential… (More)
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1997
1997
In order to clarify possible risks of aneuploidy induction in germ cells by cancer chemotherapy we studied effects of a non… (More)
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1995
1995
Merbarone, a novel DNA topoisomerase II (topo II) inhibitor, differs from teniposide (VM-26) in that it inhibits topo II… (More)
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Patients with metastatic (stage IV) non-small-cell lung cancer usually have a poor prognosis and disease refractory to… (More)
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1989
1989
Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer… (More)
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1989
1989
A 13.5-kilobase HindIII fragment, bearing an intact mercury resistance (mer) operon, was isolated from chromosomal DNA of broad… (More)
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Review
1987
Review
1987
Merbarone was developed to clinical trial stage on the basis of its ‘curative’ activity against P388 and L1210 leukemias and… (More)
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