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merbarone
Known as:
5-(N-phenylcarboxamido)-2-thiobarbituric acid
, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-
, MERB
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes…
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National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (1)
NSC 336628
Broader (2)
Thiobarbiturates
Topoisomerase II Inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase IIα Inhibitors
Hong Liang
,
Xing Wu
,
J. Yalowich
,
B. Hasinoff
Molecular Pharmacology
2008
Corpus ID: 32101889
After the identification of a new lead bisphenol compound that had good topoisomerase IIα (EC 5.99.1.3) inhibitory activity, a…
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2006
2006
A Three-Dimensional Quantitative Structure-Activity Relationship Study of the Inhibition of the ATPase Activity and the Strand Passing Catalytic Activity of Topoisomerase IIα by Substituted Purine…
L. Jensen
,
Hong Liang
,
R. Shoemaker
,
M. Grauslund
,
M. Sehested
,
B. Hasinoff
Molecular Pharmacology
2006
Corpus ID: 13699683
Based on the topoisomerase IIα catalytic inhibitory activity of a previous hit compound, NSC35866, we screened 40 substituted…
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2004
2004
NMR structural studies reveal a novel protein fold for MerB, the organomercurial lyase involved in the bacterial mercury resistance system.
P. Di Lello
,
G. Benison
,
+4 authors
J. Omichinski
Biochemistry
2004
Corpus ID: 37786630
Mercury resistant bacteria have developed a system of two enzymes (MerA and MerB), which allows them to efficiently detoxify both…
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Review
2004
Review
2004
Merbarone: an antitumor agent entering clinical trials
A. Glover
,
H. Chun
,
+5 authors
B. Leyland-Jones
Investigational new drugs
2004
Corpus ID: 29677677
SummaryMerbarone was developed to clinical trial stage on the basis of its ‘curative’ activity against P388 and L1210 leukemias…
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Review
1999
Review
1999
Bacterial detoxification of Hg(II) and organomercurials.
S. Miller
Essays in Biochemistry
1999
Corpus ID: 9260917
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0…
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Highly Cited
1997
Highly Cited
1997
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: Cell cycle arrest and induction of aneuploidy
Morko Kallio
,
J. Lähdetie
Environmental and Molecular Mutagenesis
1997
Corpus ID: 22321171
In order to clarify possible risks of aneuploidy induction in germ cells by cancer chemotherapy we studied effects of a non…
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1997
1997
Phase II trial of merbarone in patients with malignant brain tumors
U. Malik
,
J. Dutcher
,
G. Caliendo
,
P. Lasala
,
R. Mitnick
,
P. Wiernik
Medical Oncology
1997
Corpus ID: 9927450
The standard treatment for patients with primary malignant glioma includes surgical resection, radiotherapy, and nitrosourea…
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1995
1995
Inhibitors of topoisomerase II delay progress through mitosis and induce a doubling of the DNA content in CHO cells.
A. T. Sumner
Experimental Cell Research
1995
Corpus ID: 21352680
The effect of inhibition of topoisomerase II on chromosome segregation in CHO cells has been studied using cytogenetical…
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1985
1985
5-(N-phenylcarboxamido)-2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent.
A. D. Brewer
,
J. A. Minatelli
,
J. Plowman
,
K. Paull
,
V. Narayanan
Biochemical Pharmacology
1985
Corpus ID: 37285550
1982
1982
Methionine enkephalinergic neuronal activity in cerebral nuclei of spontaneously hypertensive rats.
K. Nakamura
,
T. Hayashi
HYPERTENSION
1982
Corpus ID: 17161307
The role of methionine enkephalin (ME) neurons in the development of genetic hypertension in SHR is the subject of this study…
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