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merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… 
National Institutes of Health

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3 relations

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NSC 336628

Broader (2)

ThiobarbituratesTopoisomerase II Inhibitors

Papers overview

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Highly Cited
2016
Highly Cited
2016
Anaerobic Mercury Methylation and Demethylation by Geobacter bemidjiensis Bem.
Microbial methylation and demethylation are two competing processes controlling the net production and bioaccumulation of… 
Highly Cited
2007
Highly Cited
2007
Coupling two mercury resistance genes in Eastern cottonwood enhances the processing of organomercury.
Eastern cottonwood (Populus deltoides Bartr. ex Marsh.) trees were engineered to express merA (mercuric ion reductase) and merB… 
Highly Cited
2004
Highly Cited
2004
Role of the bacterial organomercury lyase (MerB) in controlling methylmercury accumulation in mercury-contaminated natural waters.
The curious phenomenon of similar levels of methylmercury (MeHg) accumulation in fish from contaminated and pristine environments… 
Highly Cited
2003
Highly Cited
2003
Subcellular Targeting of Methylmercury Lyase Enhances Its Specific Activity for Organic Mercury Detoxification in Plants1
Methylmercury is an environmental pollutant that biomagnifies in the aquatic food chain with severe consequences for humans and… 
Highly Cited
2003
Highly Cited
2003
G2 arrest in response to topoisomerase II inhibitors: the role of p53.
We have previously found that the overexpression of p53 causes G(2) arrest and represses the synthesis of cyclin-dependent kinase… 
Review
1999
Review
1999
Bacterial detoxification of Hg(II) and organomercurials.
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… 
Highly Cited
1998
Highly Cited
1998
Merbarone Inhibits the Catalytic Activity of Human Topoisomerase IIα by Blocking DNA Cleavage*
Merbarone is a catalytic inhibitor of topoisomerase II that is in clinical trials as an anticancer agent. Despite the potential… 
Highly Cited
1991
Highly Cited
1991
Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.
Several recently developed derivatives of bis(2,6-dioxopiperazine) have been shown to be new antitumor agents and are currently… 
Highly Cited
1989
Highly Cited
1989
In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.
Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer… 
Highly Cited
1989
Highly Cited
1989
Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury resistance
A 13.5-kilobase HindIII fragment, bearing an intact mercury resistance (mer) operon, was isolated from chromosomal DNA of broad… 
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