merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… (More)
National Institutes of Health

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NSC 336628

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ThiobarbituratesTopoisomerase II Inhibitors

Papers overview

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2003
2003
Subcellular targeting of methylmercury lyase enhances its specific activity for organic mercury detoxification in plants.
Methylmercury is an environmental pollutant that biomagnifies in the aquatic food chain with severe consequences for humans and… (More)
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2002
2002
Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187.
Merbarone is a catalytic inhibitor of topoisomerase II (topo II) that has been proposed to act primarily by blocking topo II… (More)
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Review
1999
Review
1999
Bacterial detoxification of Hg(II) and organomercurials.
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… (More)
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Highly Cited
1998
Highly Cited
1998
Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.
Merbarone is a catalytic inhibitor of topoisomerase II that is in clinical trials as an anticancer agent. Despite the potential… (More)
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1997
1997
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: cell cycle arrest and induction of aneuploidy.
In order to clarify possible risks of aneuploidy induction in germ cells by cancer chemotherapy we studied effects of a non… (More)
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1995
1995
Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26.
Merbarone, a novel DNA topoisomerase II (topo II) inhibitor, differs from teniposide (VM-26) in that it inhibits topo II… (More)
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Highly Cited
1993
Highly Cited
1993
Phase II study of taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group Results.
BACKGROUND Patients with metastatic (stage IV) non-small-cell lung cancer usually have a poor prognosis and disease refractory to… (More)
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1989
1989
In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.
Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer… (More)
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1989
1989
Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury resistance.
A 13.5-kilobase HindIII fragment, bearing an intact mercury resistance (mer) operon, was isolated from chromosomal DNA of broad… (More)
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Review
1987
Review
1987
Merbarone: an antitumor agent entering clinical trials
Merbarone was developed to clinical trial stage on the basis of its ‘curative’ activity against P388 and L1210 leukemias and… (More)
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