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merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

NSC 336628

Broader (2)

ThiobarbituratesTopoisomerase II Inhibitors

Papers overview

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Highly Cited
2016
Highly Cited
2016
Anaerobic Mercury Methylation and Demethylation by Geobacter bemidjiensis Bem.
Microbial methylation and demethylation are two competing processes controlling the net production and bioaccumulation of… 
Highly Cited
2004
Highly Cited
2004
Role of the bacterial organomercury lyase (MerB) in controlling methylmercury accumulation in mercury-contaminated natural waters.
The curious phenomenon of similar levels of methylmercury (MeHg) accumulation in fish from contaminated and pristine environments… 
Review
2003
Review
2003
Catalytic topoisomerase II inhibitors in cancer therapy.
Highly Cited
2003
Highly Cited
2003
Subcellular Targeting of Methylmercury Lyase Enhances Its Specific Activity for Organic Mercury Detoxification in Plants1
Methylmercury is an environmental pollutant that biomagnifies in the aquatic food chain with severe consequences for humans and… 
Review
1999
Review
1999
Bacterial detoxification of Hg(II) and organomercurials.
  • S. Miller
  • Essays in biochemistry
  • 1999
  • Corpus ID: 9260917
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… 
Highly Cited
1998
Highly Cited
1998
Merbarone Inhibits the Catalytic Activity of Human Topoisomerase IIα by Blocking DNA Cleavage*
Merbarone is a catalytic inhibitor of topoisomerase II that is in clinical trials as an anticancer agent. Despite the potential… 
Highly Cited
1993
Highly Cited
1993
Phase II study of taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group Results.
BACKGROUND Patients with metastatic (stage IV) non-small-cell lung cancer usually have a poor prognosis and disease refractory to… 
Highly Cited
1989
Highly Cited
1989
In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.
Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer… 
Highly Cited
1989
Highly Cited
1989
Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury resistance
A 13.5-kilobase HindIII fragment, bearing an intact mercury resistance (mer) operon, was isolated from chromosomal DNA of broad… 
Highly Cited
1989
Highly Cited
1989
Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.
The p170 and p180 forms of topoisomerase II have been compared. The concentration dependence of ATP for catalytic activity of the… 
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