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merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… Expand
National Institutes of Health

Papers overview

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2016
2016
Microbial methylation and demethylation are two competing processes controlling the net production and bioaccumulation of… Expand
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Highly Cited
2004
Highly Cited
2004
The curious phenomenon of similar levels of methylmercury (MeHg) accumulation in fish from contaminated and pristine environments… Expand
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Highly Cited
2003
Highly Cited
2003
Methylmercury is an environmental pollutant that biomagnifies in the aquatic food chain with severe consequences for humans and… Expand
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Review
1999
Review
1999
  • S. Miller
  • Essays in biochemistry
  • 1999
  • Corpus ID: 9260917
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… Expand
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1999
1999
Merbarone (5-[N-phenyl carboxamido]-2-thiobarbituric acid) is an anticancer drug that inhibits the catalytic activity of DNA… Expand
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Highly Cited
1998
Highly Cited
1998
Merbarone is a catalytic inhibitor of topoisomerase II that is in clinical trials as an anticancer agent. Despite the potential… Expand
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Highly Cited
1995
Highly Cited
1995
The LlaI restriction and modification (R/M) system is encoded on pTR2030, a 46.2-kb conjugative plasmid from Lactococcus lactis… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Patients with metastatic (stage IV) non-small-cell lung cancer usually have a poor prognosis and disease refractory to… Expand
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Highly Cited
1989
Highly Cited
1989
A 13.5-kilobase HindIII fragment, bearing an intact mercury resistance (mer) operon, was isolated from chromosomal DNA of broad… Expand
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Highly Cited
1989
Highly Cited
1989
Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer… Expand
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