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merbarone

Known as: 5-(N-phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, MERB 
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

NSC 336628

Broader (2)

ThiobarbituratesTopoisomerase II Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Development of a transgenic tobacco plant for phytoremediation of methylmercury pollution
To develop the potential of plant for phytoremediation of methylmercury pollution, a genetically engineered tobacco plant that… 
2008
2008
A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase IIα Inhibitors
After the identification of a new lead bisphenol compound that had good topoisomerase IIα (EC 5.99.1.3) inhibitory activity, a… 
2007
2007
Cleaving C-Hg bonds: two thiolates are better than one
Organomercurial lyase (MerB) catalyzes the difficult cleavage of C-Hg bonds to hydrocarbon and mercuric dithiol products. Model… 
2004
2004
NMR structural studies reveal a novel protein fold for MerB, the organomercurial lyase involved in the bacterial mercury resistance system.
Mercury resistant bacteria have developed a system of two enzymes (MerA and MerB), which allows them to efficiently detoxify both… 
Review
1999
Review
1999
Bacterial detoxification of Hg(II) and organomercurials.
The most common bacterial mechanism for resistance to mercuric-ion species involves intracellular reduction of Hg(II) to Hg(0… 
Highly Cited
1997
Highly Cited
1997
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: Cell cycle arrest and induction of aneuploidy
In order to clarify possible risks of aneuploidy induction in germ cells by cancer chemotherapy we studied effects of a non… 
1997
1997
Phase II trial of merbarone in patients with malignant brain tumors
The standard treatment for patients with primary malignant glioma includes surgical resection, radiotherapy, and nitrosourea… 
Highly Cited
1995
Highly Cited
1995
In vivo restriction by LlaI is encoded by three genes, arranged in an operon with llaIM, on the conjugative Lactococcus plasmid pTR2030
The LlaI restriction and modification (R/M) system is encoded on pTR2030, a 46.2-kb conjugative plasmid from Lactococcus lactis… 
1985
1985
5-(N-phenylcarboxamido)-2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent.
1982
1982
Methionine enkephalinergic neuronal activity in cerebral nuclei of spontaneously hypertensive rats.
The role of methionine enkephalin (ME) neurons in the development of genetic hypertension in SHR is the subject of this study… 
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