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Interactive Association of Drugs Binding to Human Serum Albumin
TLDR
This review will succinctly outline the properties of binding site of drugs in IIA subdomain within the structure of HSA to give an overview on the binding characterization of interactive association of drugs to human serum albumin that may potentially lead to significant clinical applications. Expand
In vivo epidermal migration requires focal adhesion targeting of ACF7
TLDR
It is demonstrated that the phosphorylation of ACF7 plays an indispensable role in focal adhesion dynamics and epidermal migration in vitro and in vivo and provides critical insights into the molecular mechanisms underlying coordinated cytoskeletal dynamics during cell movement. Expand
Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
TLDR
Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand. Expand
Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor
TLDR
A novel pathway for epithelial cells apoptosis/cytolysis is revealed by inducing different toxic stresses and their modulation by using ionic solutions. Expand
Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha.
TLDR
These studies have elucidated some of the chemistry and biological activities of the interaction of thimerosal with topoisomerase II alpha and protein and nonprotein thiols and with DNA. Expand
Corneal Protection With High-Molecular-Weight Hyaluronan Against In Vitro and In Vivo Sodium Lauryl Sulfate-Induced Toxic Effects
TLDR
In vivo data indicate that SLS cornea injuries, characterized by damaged corneal epithelium, damaged anterior stroma, and inflammatory infiltrations, were attenuated with HA-HMW treatment. Expand
Developing an Anticancer Copper(II) Pro-Drug Based on the His242 Residue of the Human Serum Albumin Carrier IIA Subdomain.
TLDR
In vivo data revealed that the HSA-Cu( Bp44 mT) complex increased copper's selectivity and capacity of inhibiting tumor growth compared to Cu(Bp44mT)Cl alone. Expand
Folate-functionalized human serum albumin carrier for anticancer copper(II) complexes derived from natural plumbagin.
TLDR
Compared with Cu(II) complex alone, FA-HSA-metallodrug complex enhances cytotoxicity to FA-positive cancer cells (HeLa) but do not raise cytot toxicity levels in normal cells in vitro through selectively accumulating in cancer cells to some extent. Expand
Enhancing the copper(II) complexes cytotoxicity to cancer cells through bound to human serum albumin.
TLDR
Compared with C3 alone, HSA-C3 complex promotes HepG2 cell apoptosis and has a stronger capacity to promote cell cycle arrest at the G2/M phase of HepG 2. Expand
Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin.
TLDR
In vivo data showed that 4b and the HSA-PA-4b complex inhibit lung tumor growth, and the targeting ability and therapeutic efficacy of the PA-modified HSA complex was stronger than 4b alone. Expand
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