T. Klaenhammer

Publications357
h-index89
Citations31,841
Highly Influential Citations1,313
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Genetics of bacteriocins produced by lactic acid bacteria.
  • T. Klaenhammer
  • Biology, Medicine
    FEMS microbiology reviews
  • 1 September 1993
TLDR
The biochemical and genetic characteristics of these antimicrobial proteins are reviewed and common elements are discussed between the different classes of bacteriocins produced by these Gram-positive bacteria.
Comparative genomics of the lactic acid bacteria
TLDR
Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.
Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM.
TLDR
These features within the genome sequence of L. acidophilus are likely to contribute to the organisms' gastric survival and promote interactions with the intestinal mucosa and microbiota.
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different…
S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions
TLDR
The major S layer protein, SlpA, of L. acidophilus NCFM is the first probiotic bacterial DC-SIGN ligand identified that is functionally involved in the modulation of DCs and T cells functions.
The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.
TLDR
Genome analysis predicted an abundance of large and unusual cell-surface proteins, including fimbrial subunits, which may be involved in adhesion to glycoproteins or other components of mucin, a characteristic expected to affect persistence in the gastrointestinal tract (GIT).
Bacteriocins of lactic acid bacteria.
Functional Analysis of Putative Adhesion Factors in Lactobacillus acidophilus NCFM
TLDR
It is demonstrated that multiple cell surface proteins in L. acidophilus NCFM can individually contribute to the organism's ability to attach to intestinal cells in vitro.
Factors involved in adherence of lactobacilli to human Caco-2 cells
TLDR
The results indicate that Lactobacillus species adhere to human intestinal cells via mechanisms which involve different combinations of carbohydrate and protein factors on the bacterial cell surface.
Detection and activity of lactacin B, a bacteriocin produced by Lactobacillus acidophilus.
TLDR
Examination of strains of L. acidophilus within the six homology groupings of Johnson et al. demonstrated that production of the bacteriocin lactacin B could not be used in classification of neotype L. Acidophilus strains, however, the usefulness of employing sensitivity to lactac in B in classified of dairy lactobacilli is suggested.
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