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melatonin biosynthetic process

Known as: melatonin synthesis, melatonin formation, melatonin anabolism 
The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine). [GOC:mah, ISBN:0198506732]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2017
051019682017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland
The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals… (More)
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Highly Cited
2008
Highly Cited
2008
Abnormal melatonin synthesis in autism spectrum disorders
Melatonin is produced in the dark by the pineal gland and is a key regulator of circadian and seasonal rhythms. A low melatonin… (More)
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2007
2007
Evidence for melatonin synthesis in the rat brain during development.
Melatonin production is not restricted to the pineal gland. Several extrapineal sources of this indole such as retina, Harderian… (More)
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2005
2005
N-acetyltransferase is not the rate-limiting enzyme of melatonin synthesis at night.
Circadian melatonin production in the pineal gland and retina is under the control of serotonin N-acetyltransferase (NAT) and… (More)
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2005
2005
Pineal hormone melatonin oscillates also in the dinoflagellateGonyaulax polyedra
Periodic organization represents the basis for temporal orientation corresponding to environmental changes in illumination. The… (More)
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Highly Cited
2004
Highly Cited
2004
Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance.
It has been historically assumed that the pineal gland is the major source of melatonin (N-acetyl-5-methoxytryptamine) in… (More)
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2003
2003
Suprachiasmatic control of melatonin synthesis in rats: inhibitory and stimulatory mechanisms.
The suprachiasmatic nucleus (SCN) controls the circadian rhythm of melatonin synthesis in the mammalian pineal gland by a… (More)
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Highly Cited
2001
Highly Cited
2001
Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat.
Besides the pineal gland, melatonin is reported to be produced in a number of extrapineal sites, where it could act as an… (More)
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Highly Cited
1998
Highly Cited
1998
The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration.
Melatonin is synthesized rhythmically under control of circadian oscillators by the retinas of non-mammalian vertebrates. Here we… (More)
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1994
1994
The suprachiasmatic nucleus controls the circadian rhythm of heart rate via the sympathetic nervous system.
The mammalian suprachiasmatic nucleus (SCN) controls a wide variety of circadian behavioral and physiological processes. The… (More)
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