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The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care*
Objective:Critically ill patients require high-intensity care and may be at especially high risk of iatrogenic injury because they are severely ill. We sought to study the incidence and nature ofExpand
Measuring and using light in the melanopsin age
Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythmExpand
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
STUDY OBJECTIVES To assess the wavelength-dependent sensitivity of the acute effects of ocular light exposure on alertness, performance, waking electroencephalogram (EEG), and cortisol. DESIGN AExpand
Effect of reducing interns' work hours on serious medical errors in intensive care units.
BACKGROUND Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors. METHODS We conducted a prospective, randomizedExpand
High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light.
The endogenous circadian oscillator in mammals, situated in the suprachiasmatic nuclei, receives environmental photic input from specialized subsets of photoreceptive retinal ganglion cells. TheExpand
Sleep disorders, health, and safety in police officers.
CONTEXT Sleep disorders often remain undiagnosed. Untreated sleep disorders among police officers may adversely affect their health and safety and pose a risk to the public. OBJECTIVE To quantifyExpand
Melatonin administration can entrain the free-running circadian system of blind subjects.
Although melatonin treatment has been shown to phase shift human circadian rhythms, it still remains ambiguous as to whether exogenous melatonin can entrain a free-running circadian system. We haveExpand
Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light
Light resets the circadian clock through a non–image-forming receptor system—or so it was thought; now, cone photoreceptors are shown to also participate. Retinal Receptors Conspire to Keep Us AwakeExpand
Meeting Report: The Role of Environmental Lighting and Circadian Disruption in Cancer and Other Diseases
Light, including artificial light, has a range of effects on human physiology and behavior and can therefore alter human physiology when inappropriately timed. One example of potential light-inducedExpand
Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans.
CONTEXT Millions of individuals habitually expose themselves to room light in the hours before bedtime, yet the effects of this behavior on melatonin signaling are not well recognized. OBJECTIVE WeExpand