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An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans
1 Non‐image forming, irradiance‐dependent responses mediated by the human eye include synchronisation of the circadian axis and suppression of pineal melatonin production. The retinal photopigment(s)Expand
Melatonin and the Mammalian Pineal Gland
Foreword. Melatonin and the mammalian pineal gland. Structure of the pineal gland. Biochemistry of the pineal. Light-dark control of melatonin synthesis. Physiology of the pineal: role inExpand
A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.
STUDY OBJECTIVES To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. DESIGN Subjects were genotyped using polymerase chainExpand
Melatonin: Characteristics, Concerns, and Prospects
  • J. Arendt
  • Biology, Medicine
  • Journal of biological rhythms
  • 1 August 2005
Melatonin is of great importance to the investigation of human biological rhythms. Its rhythm in plasma or saliva provides the best available measure of the timing of the internal circadian clock.Expand
Direct radioimmunoassay for melatonin in plasma.
Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology.
  • J. Arendt
  • Biology, Medicine
  • Reviews of reproduction
  • 1998
The pineal hormone melatonin is secreted with a marked circadian rhythm. Normally, maximum production occurs during the dark phase of the day and the duration of secretion reflects the duration ofExpand
Health in a 24-h society
With increasing economic and social demands, we are rapidly evolving into a 24-h society. In any urban economy, about 20% of the population are required to work outside the regular 0800-1700 hExpand
Melatonin administration can entrain the free-running circadian system of blind subjects.
Although melatonin treatment has been shown to phase shift human circadian rhythms, it still remains ambiguous as to whether exogenous melatonin can entrain a free-running circadian system. We haveExpand
Melatonin and Human Rhythms
  • J. Arendt
  • Biology, Medicine
  • Chronobiology international
  • 1 January 2006
Melatonin signals time of day and time of year in mammals by virtue of its pattern of secretion, which defines ‘biological night.’ It is supremely important for research on the physiology andExpand
Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans
Melatonin is able to phase-shift the endogenous circadian clock and can induce acute temperature suppression. It is possible that there is a direct relationship between these phenomena. In aExpand