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mecasermin

Known as: Recombinant Insulin-Like Growth Factor 1, IGF1, IGF-1 
Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity. Clinical Use: Diabetes Mellitus and Amyotrophic Lateral… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

Growth SubstancesInsulin-Like Growth Factor I
IGF1 protein, humanIncrelexmecasermin 10 MG/ML Injectable Solution [Increlex]mecasermin rinfabate

Narrower (1)

Myotrophin brand of mecasermin

Papers overview

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Review
2017
Review
2017
GH and ageing: Pitfalls and new insights.
Highly Cited
2001
Highly Cited
2001
The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors
Highly Cited
1999
Highly Cited
1999
Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with…
Mitogenic signal-transduction pathways have not been well defined in pancreatic beta-cells. In the glucose-sensitive rat beta… 
Highly Cited
1997
Highly Cited
1997
Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin-like growth factor 1, insulin-like growth factor binding proteins 1 and 3, and osteocalcin.
OBJECTIVE To investigate possible mechanisms of growth impairment in children with juvenile rheumatoid arthritis (JRA). METHODS… 
Highly Cited
1993
Highly Cited
1993
Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.
The solution structure of human insulin-like growth factor 1 has been investigated with a combination of nuclear magnetic… 
Highly Cited
1993
Highly Cited
1993
Ring chromosome 15 involving deletion of the insulin-like growth factor 1 receptor gene in a patient with features of Silver-Russell syndrome.
An 11-year-old girl with de novo r(15) (p12q26.3) with a clinical diagnosis of Silver-Russell syndrome (SRS) is presented. She… 
Highly Cited
1992
Highly Cited
1992
Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.
BALB/c3T3 cells are exquisitely growth regulated and require both platelet-derived growth factor and insulin-like growth factor-1… 
Highly Cited
1989
Highly Cited
1989
Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide.
Highly Cited
1989
Highly Cited
1989
Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.
The GTPase-activating protein (GAP) has been postulated to function either as a negative regulator or as a possible target… 
Highly Cited
1986
Highly Cited
1986
Rapid microassay for protein kinase C translocation in Swiss 3T3 cells.
The Ca2+/phosphatidylserine-stimulated protein kinase C (PKC) appears to exist as interconvertible inactive, soluble and active… 
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