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mecasermin

Known as: Recombinant Insulin-Like Growth Factor 1, IGF1, IGF-1 
Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity. Clinical Use: Diabetes Mellitus and Amyotrophic Lateral… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

Growth SubstancesInsulin-Like Growth Factor I
IGF1 protein, humanIncrelexmecasermin 10 MG/ML Injectable Solution [Increlex]mecasermin rinfabate

Narrower (1)

Myotrophin brand of mecasermin

Papers overview

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Review
2010
Review
2010
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies.
Highly Cited
2010
Highly Cited
2010
Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice
Rationale: Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are… 
Review
2009
Review
2009
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
The embryonic program ‘epithelial-mesenchymal transition’ (EMT) is activated during tumor invasion in disseminating cancer cells… 
Highly Cited
2007
Highly Cited
2007
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
The insulin-like growth factor 1 (IGF-1)-AKT-mTOR pathways sense the availability of nutrients and mitogens and respond by… 
Highly Cited
2007
Highly Cited
2007
A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits… 
Highly Cited
2005
Highly Cited
2005
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function.
The purpose of this study was to determine whether the heart in large mammals contains cardiac progenitor cells that regulate… 
Highly Cited
2004
Highly Cited
2004
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.
Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the… 
Highly Cited
2003
Highly Cited
2003
Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of… 
Highly Cited
2001
Highly Cited
2001
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.
To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth… 
Highly Cited
1996
Highly Cited
1996
Effects of an Igf1 gene null mutation on mouse reproduction.
Both sexes of adult mice homozygous for a targeted mutation of the Igf1 gene, encoding insulin-like growth factor 1, are… 
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