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Structural Basis of Integrin Activation by Talin
TLDR
The structural basis of talin's unique ability to activate integrins is revealed, an interaction that could aid in the design of therapeutics to block integrin activation is identified, and engineering of cells with defects in the activation of multiple classes of integrin is enabled. Expand
Integrin structure, activation, and interactions.
TLDR
This review summarizes recent progress in the structural and molecular functional studies of this important class of adhesion receptor. Expand
Talins and kindlins: partners in integrin-mediated adhesion
TLDR
New data reveal the domain structure of full-length talin, provide insights into talin-mediated integrin activation and show that RIAM recruits talin to the plasma membrane, whereas vinculin stabilizes talin in cell–matrix junctions. Expand
Structural determinants of integrin recognition by talin.
TLDR
The crystal structure of the principal integrin binding and activating fragment of talin is reported, alone and in complex with fragments of the beta 3 integrin tail, providing structural paradigms for integrin linkage to the cell interior. Expand
The molecular basis of filamin binding to integrins and competition with talin.
TLDR
The high-resolution structure of an interface between filamin A and an integrin adhesion receptor is described and it is suggested that this interface is a prototype for other IgFLN domain interactions. Expand
The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction
TLDR
This work reports the first structure of talin bound to an authentic full‐length β integrin tail and identifies a positively charged surface on the talin F2 domain that precisely orients talin to disrupt the heterodimeric integrin transmembrane (TM) complex. Expand
Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper.
TLDR
This work shows the structure of a streptococcal FnBP peptide (B3) in complex with the module pair 1F12F1 and identifies 1F1- and 2F 1-binding motifs in B3 that form additional antiparallel beta-strands on sequential F1 modules-the first example of a tandem beta-zipper. Expand
Structures of the Cd44–hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction
TLDR
It is revealed that the interaction with hyaluronan is dominated by shape and hydrogen-bonding complementarity and two conformational forms of the receptor that differ in orientation of a crucial hyAluronan-binding residue (Arg45, equivalent to Arg41 in human CD44). Expand
Amyloid fibril formation by an SH3 domain.
TLDR
Results indicate that the A state of PI3-SH3 is partially folded and support the hypothesis that partially folded states formed in solution are precursors of amyloid deposition. Expand
The GTPase dynamin binds to and is activated by a subset of SH3 domains
TLDR
Dynamin GTPase activity is stimulated by several of the bound SH3 domains, suggesting that the function of the SH3 module is not restricted to protein-protein interactions but may also include the interactive regulation of GTP-binding proteins. Expand
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