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mafosfamide

Known as: 2-((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid P-oxide 
A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA… Expand
National Institutes of Health

Papers overview

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Review
2014
Review
2014
PURPOSE To date, response criteria and optimal methods for assessment of outcome have not been standardized in patients with… Expand
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2014
2014
Aldehyde dehydrogenase enzymes irreversibly oxidize aldehydes generated from metabolism of amino acids, fatty acids, food, smoke… Expand
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Highly Cited
2006
Highly Cited
2006
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
Highly Cited
2005
Highly Cited
2005
PURPOSE Preclinical studies of mafosfamide, a preactivated cyclophosphamide analog, were performed to define a tolerable and… Expand
Highly Cited
2000
Highly Cited
2000
Previous studies in this laboratory showed that the overexpression of human aldehyde dehydrogenase class-1 (ALDH-1) with a… Expand
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Highly Cited
1994
Highly Cited
1994
A total of 125 acute leukemia adult patients were autografted with bone marrow (BM) purged by mafosfamide (ASTA Z) during the… Expand
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Highly Cited
1993
Highly Cited
1993
Synthetic oligodeoxynucleotides complementary to the break-point junction of bcr-abl transcripts selectively inhibit the… Expand
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Highly Cited
1991
Highly Cited
1991
Fifty-nine European teams have reported 919 autografts for the consolidation of acute myelocytic leukemia (AML) up to December 31… Expand
Highly Cited
1990
Highly Cited
1990
The knowledge about drug resistance in childhood leukemias and acute lymphoblastic leukemia (ALL) in general is limited. This is… Expand
Review
1990
Review
1990
We analyzed data from 263 patients with acute myelocytic leukemia (AML) autografted in first remission (CR) during the period… Expand
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