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mafosfamide

Known as: 2-((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid P-oxide 
A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Antineoplastic AgentsCyclophosphamideImmunologic Adjuvants
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (1)

z 7557

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Insights into oxazaphosphorine resistance and possible approaches to its circumvention.
2000
2000
Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3.
1998
1998
Intrathecal mafosfamide therapy for pediatric brain tumors with meningeal dissemination
The treatment of childhood brain tumors with cerebrospinal fluid (CSF) dissemination is limited by the relative inaccessibility… 
1995
1995
Phenolic antioxidant-induced overexpression of class-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance.
1994
1994
Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes.
1994
1994
Autologous transplant for chronic myelogenous leukemia using marrow treated ex vivo with mafosfamide.
Ten adult patients with Ph-positive chronic myelogenous leukemia (CML) received autologous transplantation using marrow treated… 
Highly Cited
1991
Highly Cited
1991
DNA damage, poly (ADP-ribosyl)ation and apoptotic cell death as a potential common pathway of cytotoxic drug action.
1991
1991
In vitro marrow purging in chronic myelogenous leukemia: effect of mafosfamide and recombinant granulocyte--macrophage colony-stimulating factor.
Clinical and experimental evidence revealing Ph1-negative hematopoietic stem cells in the majority of chronic myelogenous… 
1987
1987
Comparison of the sensitivity of normal and leukaemic myeloid progenitors to in-vitro incubation with cytotoxic drugs: a study of pharmacological purging.
1987
1987
Limiting-dilution analysis for the determination of leukemic cell frequencies after bone marrow decontamination with mafosfamide or merocyanine 540.
To stimulate a leukemia remission marrow, cell suspensions of normal human bone marrow were mixed with human acute lymphoblastic… 
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