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mafosfamide

Known as: 2-((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid P-oxide 
A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Regulatory T cells become resistant to cyclophosphamide after allogeneic stimulation, protecting against GVHD. Taming Graft… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE Preclinical studies of mafosfamide, a preactivated cyclophosphamide analog, were performed to define a tolerable and… Expand
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Highly Cited
2001
Highly Cited
2001
The ABL-specific tyrosine kinase inhibitor STI571 (formerly CGP57148B) induced cytogenetic remissions in 33% of chronic… Expand
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Highly Cited
2001
Highly Cited
2001
Cyclophosphamide (CPA), a widely used oxazaphosphorine anti-cancer prodrug, is inactive until it is metabolized by cytochrome… Expand
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Highly Cited
2000
Highly Cited
2000
Previous studies in this laboratory showed that the overexpression of human aldehyde dehydrogenase class-1 (ALDH-1) with a… Expand
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1994
1994
Ten adult patients with Ph-positive chronic myelogenous leukemia (CML) received autologous transplantation using marrow treated… Expand
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Highly Cited
1994
Highly Cited
1994
A total of 125 acute leukemia adult patients were autografted with bone marrow (BM) purged by mafosfamide (ASTA Z) during the… Expand
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Highly Cited
1993
Highly Cited
1993
Synthetic oligodeoxynucleotides complementary to the break-point junction of bcr-abl transcripts selectively inhibit the… Expand
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Highly Cited
1991
Highly Cited
1991
: Fifty-nine European teams have reported 919 autografts for the consolidation of acute myelocytic leukemia (AML) up to December… Expand
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Highly Cited
1990
Highly Cited
1990
The knowledge about drug resistance in childhood leukemias and acute lymphoblastic leukemia (ALL) in general is limited. This is… Expand
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