Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs
- Shufeng Zhou, S. Chan, H. McLeod
- Biology, ChemistryClinical Pharmacokinetics
- 2005
It appears that the chemical properties of a drug critical to CYP3A4 inactivation include formation of reactive metabolites by CYP isoenzymes, preponderance of CYP inducers and P-glycoprotein (P-gp) substrate, and occurrence of clinically significant pharmacokinetic interactions with coadministered drugs.
Interactions of Herbs with Cytochrome P450
- Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, A. Xu, J. Paxton
- Biology, ChemistryDrug metabolism reviews (Softcover ed.)
- 1 January 2003
Given that increasing numbers of people are exposed to a number of herbal preparations that contain many constituents with potential of CYP modulation, high-throughput screening assays should be developed to explore herb–CYP interactions.
Herbal Modulation of P‐Glycoprotein
- Shufeng Zhou, L. Lim, B. Chowbay
- Biology, ChemistryDrug metabolism reviews (Softcover ed.)
- 1 January 2004
The inhibition of PGP by herbal constituents may provide a novel approach for reversing multidrug resistance in tumor cells, whereas the stimulation of Pgp expression or activity has implication for chemoprotective enhancement by herbal medicines.
Herb-drug interactions: a literature review.
- Zeping Hu, Xiaoxia Yang, Shufeng Zhou
- Medicine, BiologyDrugs
- 2005
Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions…
Role of Hydrogen Sulfide in the Cardioprotection Caused by Ischemic Preconditioning in the Rat Heart and Cardiac Myocytes
- J. Bian, Q. Yong, P. Moore
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 February 2006
It is suggested that endogenous H2S contributes to cardioprotection induced by IP, which effect may involve protein kinase C and sarcolemmal KATP channels.
Clinical Pharmacology of Cyclophosphamide and Ifosfamide
- Jing Zhang, Quan Tian, Shufeng Zhou
- Biology, Chemistry
- 2006
The oxazaphosphorine cyclophosphamide (CPA) and ifosfamide (IFO) are two commonly used DNA- alkylating agents in cancer chemotherapy and the pharmacokinetics and pharmacodynamics of the two important agents are highlighted.
Metabolism and Transport of Oxazaphosphorines and the Clinical Implications
- Jing Zhang, Quan Tian, Yi-Zhun Zhu
- Biology, ChemistryDrug metabolism reviews (Softcover ed.)
- 1 January 2005
This review highlights the metabolism and transport of these oxazaphosphorines (mainly CPA and IFO, as these two oxazphosphorine drugs are the most widely used alkylating agents) and the clinical implications.
Herbal bioactivation: The good, the bad and the ugly
- Shufeng Zhou, H. Koh, Yihuai Gao, Z. Gong, E. Lee
- Biology, ChemistryLife Science
- 6 November 2003
Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4.
- Shufeng Zhou, E. Chan, A. Xu
- Biology, MedicineCurrent drug metabolism
- 30 September 2004
Compared to reversible inhibition, mechanism-based inhibitors of CYP3A4 more frequently cause unfavorable drug-drug interactions, as the inactivated CYP 3A4 has to be replaced by newly synthesized CYP2A4 protein.
Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance
- Shufeng Zhou, E. Chan, W. Duan, Min Huang, Yu-Zong Chen
- Biology, ChemistryDrug metabolism reviews (Softcover ed.)
- 1 January 2005
A number of therapeutic drugs with different structures and mechanisms of action have been reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes. The bioactivation…
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