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Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.
The formation of the pharmacologically active thiol form from dimesna is associated with the consumption of equimolar concentrations of reduced glutathione.
Chemical stability and fate of the cytostatic drug ifosfamide and its N-dechloroethylated metabolites in acidic aqueous solutions.
31P NMR spectroscopy was used to study the products of the decomposition of the antitumor drug ifosfamide and its N-dechloroethylated metabolites, and their degradation compounds could provide an indirect and accurate estimation of chloroacetaldehyde amounts formed from CP or IF.
D-19575—a sugar-linked isophosphoramide mustard derivative exploiting transmembrane glucose transport
D-19575 is a new alkylating cytotoxic agent with increased antitumor selectivity, probably caused by an active transmembrane transport mechanism.
Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent
The results indicate that the DNA crosslinks are the most critical cytotoxic lesions induced by β- D -glc-IPM.
Pharmacokinetics and whole-body distribution of the new chemotherapeutic agent β-D-glucosylisophosphoramide mustard and its effects on the incorporation of [methyl-3H]-thymidine in various tissues of
The effects of β-D-Glc-IPM on the incorporation of [methyl-3H]-thymidine into the DNA of the liver, kidneys, thymus, spleen, esophagus, and bone marrow of the rat were examined following tissue excision and liquid scintillation counting after administration of the drug.
Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.
The urotoxicity of oxazaphosphorine cytostatics is not based on their alkylating activity but on the presence of acrolein, which is spontaneously formed in the urine from the primary metabolites