J. Pohl

Publications49
h-index20
Citations1,468
Highly Influential Citations37
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Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.
TLDR
The formation of the pharmacologically active thiol form from dimesna is associated with the consumption of equimolar concentrations of reduced glutathione.
Chemical stability and fate of the cytostatic drug ifosfamide and its N-dechloroethylated metabolites in acidic aqueous solutions.
TLDR
31P NMR spectroscopy was used to study the products of the decomposition of the antitumor drug ifosfamide and its N-dechloroethylated metabolites, and their degradation compounds could provide an indirect and accurate estimation of chloroacetaldehyde amounts formed from CP or IF.
Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--I. Experimental studies on the urotoxicity of alkylating compounds.
Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna).
D-19575—a sugar-linked isophosphoramide mustard derivative exploiting transmembrane glucose transport
TLDR
D-19575 is a new alkylating cytotoxic agent with increased antitumor selectivity, probably caused by an active transmembrane transport mechanism.
Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent
TLDR
The results indicate that the DNA crosslinks are the most critical cytotoxic lesions induced by β- D -glc-IPM.
High-dose ifosfamide and mesna as continuous infusion over five days--a phase I/II trial.
Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention. 2. Comparative study on the uroprotective efficacy of thiols and other sulfur compounds.
Pharmacokinetics and whole-body distribution of the new chemotherapeutic agent β-D-glucosylisophosphoramide mustard and its effects on the incorporation of [methyl-3H]-thymidine in various tissues of…
TLDR
The effects of β-D-Glc-IPM on the incorporation of [methyl-3H]-thymidine into the DNA of the liver, kidneys, thymus, spleen, esophagus, and bone marrow of the rat were examined following tissue excision and liquid scintillation counting after administration of the drug.
Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.
The urotoxicity of oxazaphosphorine cytostatics is not based on their alkylating activity but on the presence of acrolein, which is spontaneously formed in the urine from the primary metabolites…
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